Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Di, Chen"'
Autor:
Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Jin
Publikováno v:
eLife, Vol 13 (2024)
Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy (HA). Drastic degradation of cartilage is a major characteristic of HA, but its pathological mechanisms has not yet been clarified. In HA cartilages, we found se
Externí odkaz:
https://doaj.org/article/a5510fb5ce96417ebb45f1787762b026
Autor:
Chenjie Xia, Huihui Xu, Liang Fang, Jiali Chen, Wenhua Yuan, Danqing Fu, Xucheng Wang, Bangjian He, Luwei Xiao, Chengliang Wu, Peijian Tong, Di Chen, Pinger Wang, Hongting Jin
Publikováno v:
eLife, Vol 12 (2024)
Glucocorticoid-induced osteonecrosis of the femoral head (GONFH) is a common refractory joint disease characterized by bone damage and the collapse of femoral head structure. However, the exact pathological mechanisms of GONFH remain unknown. Here, w
Externí odkaz:
https://doaj.org/article/e5c637d8ff124f4ebbbe32b1a1b5d422
Publikováno v:
eLife, Vol 12 (2023)
Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression. Cyclin D1 has been recognized as an oncogene since it was upregulated in several different types of c
Externí odkaz:
https://doaj.org/article/a1d06f17f003459d875fa6e1dddefd44
Autor:
Huanqing Gao, Yiming Zhong, Liang Zhou, Sixiong Lin, Xiaoting Hou, Zhen Ding, Yan Li, Qing Yao, Huiling Cao, Xuenong Zou, Di Chen, Xiaochun Bai, Guozhi Xiao
Publikováno v:
eLife, Vol 12 (2023)
Inflammatory liver diseases are a major cause of morbidity and mortality worldwide; however, underlying mechanisms are incompletely understood. Here we show that deleting the focal adhesion protein Kindlin-2 expression in hepatocytes using the Alb-Cr
Externí odkaz:
https://doaj.org/article/aef22c3fb711426a900e37e0b93b8e7c
Autor:
Rong Xie, Dan Yi, Daofu Zeng, Qiang Jie, Qinglin Kang, Zeng Zhang, Zhenlin Zhang, Guozhi Xiao, Lin Chen, Liping Tong, Di Chen
Publikováno v:
eLife, Vol 11 (2022)
Axin1 is a key regulator of canonical Wnt signaling pathway. Roles of Axin1 in skeletal development and in disease occurrence have not been fully defined. Here, we report that Axin1 is essential for lower limb development. Specific deletion of Axin1
Externí odkaz:
https://doaj.org/article/f1882fe9f96941eb8be0accd3a87bb45
Publikováno v:
eLife, Vol 11 (2022)
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial hyperplasia. Mir204 and Mir211 are homologous miRNAs with the same gene targeting spectrum. It is known that Mir204/211 play an important role in protecting o
Externí odkaz:
https://doaj.org/article/2a3dff1ef34f406bbea0875f0d76610b
Autor:
Meng Huang, Minjie Hong, Xinhao Hou, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, Xuezhu Feng
Publikováno v:
eLife, Vol 11 (2022)
Histone methylation plays crucial roles in the development, gene regulation, and maintenance of stem cell pluripotency in mammals. Recent work shows that histone methylation is associated with aging, yet the underlying mechanism remains unclear. In t
Externí odkaz:
https://doaj.org/article/a9f060b4e6004ef590e618c4c04a6547
Autor:
Han Xiao, Tao Zhang, Changjun Li, Yong Cao, Linfeng Wang, Huabin Chen, Shengcan Li, Changbiao Guan, Jianzhong Hu, Di Chen, Can Chen, Hongbin Lu
Publikováno v:
eLife, Vol 11 (2022)
Proper mechanical stimulation can improve rotator cuff enthesis injury repair. However, the underlying mechanism of mechanical stimulation promoting injury repair is still unknown. In this study, we found that Prrx1+ cell was essential for murine rot
Externí odkaz:
https://doaj.org/article/d8602af2db634d718be92574ccde701e
Autor:
Xiaoting Hou, Sixiong Lin, Liang Zhou, Yiming Zhong, Huanqing Gao, Zhen Ding, Yan Li, Qing Yao, Huiling Cao, Xuenong Zou, Di Chen, Xiaochun Bai, Guozhi Xiao
Publikováno v:
eLife. 12
Inflammatory liver diseases are a major cause of morbidity and mortality worldwide; however, underlying mechanisms are incompletely understood. Here we show that deleting the focal adhesion protein Kindlin-2 in hepatocytes using the Alb-Cre transgeni
Autor:
Dan Yi, Rong Xie, Daofu Zeng, Qiang Jie, Qinglin Kang, Zeng Zhang, Zhenlin Zhang, Guozhi Xiao, Lin Chen, Liping Tong, Di Chen
Publikováno v:
eLife. 11
Axin1 is a key regulator of canonical Wnt signaling pathway. Roles of Axin1 in skeletal development and in disease occurrence have not been fully defined. Here, we report that Axin1 is essential for lower limb development. Specific deletion of Axin1