Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christopher J. Schofield"'
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Autor:
Liudi Yao, Christopher J Brereton, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb SN Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones
Publikováno v:
eLife. 11
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-functio
Autor:
Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe
Publikováno v:
eLife, Vol 8 (2019)
Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enz
Autor:
Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield
Publikováno v:
eLife, Vol 7 (2018)
eLife
Pettinati, I, Grzechnik, P, de Almeida, C R, Brem, J, McDonough, M A, Dhir, S, Proudfoot, N J & Schofield, C J 2018, ' Biosynthesis of histone messenger RNA employs a specific 3’ end endonuclease ', eLife, vol. 7, e39865 . https://doi.org/10.7554/eLife.39865
eLife
Pettinati, I, Grzechnik, P, de Almeida, C R, Brem, J, McDonough, M A, Dhir, S, Proudfoot, N J & Schofield, C J 2018, ' Biosynthesis of histone messenger RNA employs a specific 3’ end endonuclease ', eLife, vol. 7, e39865 . https://doi.org/10.7554/eLife.39865
Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3’ stem-loop instead of the otherwise universal polyA tail. A metallo b-lactamase (MBL) fold enzyme, cleavage and polya
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Autor:
Christopher J Brereton, Liudi Yao, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb SN Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones
Publikováno v:
eLife, Vol 11 (2022)
Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-functio
Externí odkaz:
https://doaj.org/article/c0c5b337cbd6410caef8f61e40897d8b