Zobrazeno 1 - 10
of 62
pro vyhledávání: '"11"'
Autor:
Ilpo Huhtaniemi, Joanna Stelmaszewska, Maria Sztachelska, Donata Ponikwicka-Tyszko, Piotr Bernaczyk, Jacek Szamatowicz, Nafis A. Rahman, Marcin Chrusciel, Slawomir Wolczynski, Paulina Chrusciel, Mika Scheinin, Mariusz Bidziński
Publikováno v:
EBioMedicine
Background Recent clinical trials on ovarian cancer with mifepristone (MF) have failed, despite in vitro findings on its strong progesterone (P4) antagonist function. Methods Ovarian cancer human and murine cell lines, cultured high-grade human prima
Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1
Autor:
Wen Jin, Xine Shi, Jessica C. Page, Shihuan Kuang, Naagarajan Narayanan, Yan Xiong, Tizhong Shan, Zhihao Jia, Feng Yue, Riyi Shi, Meng Deng, Gongshe Yang, Chao Wang, Keping Hu
Publikováno v:
EBioMedicine
EBioMedicine, Vol 24, Iss C, Pp 127-136 (2017)
EBioMedicine, Vol 24, Iss C, Pp 127-136 (2017)
Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity. The tumor suppressor liver kinase b1 (Lkb1) is a key regulator of cellular energ
Autor:
Henry Ng, Mia Phillipson, Kim Blom, Ulrika Marking, Sara M. Mangsbo, Peter Nilsson, Ann-Christin Salomonsson, Sophia Hober, Sebastian Havervall, Charlotte Thålin, Max Gordon, Jonas Klingstrom, Nina Greilert-Norin, Mikael Åberg, Cecilia Hellström, Elisa Pin
Publikováno v:
EBioMedicine
EBioMedicine, Vol 70, Iss, Pp 103523-(2021)
EBioMedicine, Vol 70, Iss, Pp 103523-(2021)
Background Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expr
Autor:
Atara Posner, Andrew D Pattison, Joshy George, Carolyn A. Paisie, Stephen B. Fox, Yue Zhao, Kanwal Pratap Singh Raghav, Sheng Li, Honey V. Reddi, Anthony J. Gill, R. Krishna Murthy Karuturi, Ziwei Pan, Jens Rueter, Shiva Balachander, Richard W. Tothill, Sandeep Namburi, William F. Flynn
Publikováno v:
EBioMedicine, Vol 61, Iss, Pp 103030-(2020)
EBioMedicine
EBioMedicine
Background Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's pri
Autor:
Xiaojun Liu, Kirsty Danielson, Anthony Rosenzweig, Michael Jerosch-Herold, Jane E. Freedman, Avash Das, Ravi V. Shah, Chunyang Xiao, Siddique Abbasi, Bobak Heydari, Raymond Y. Kwong, Kahraman Tanriverdi, Kendall Van Keuren-Jensen, Yaoyu E. Wang, Saumya Das, Ashish Yeri, Fernando Camacho Garcia, Michael G. Silverman
Publikováno v:
EBioMedicine, Vol 32, Iss, Pp 172-181 (2018)
EBioMedicine
EBioMedicine
Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac
Autor:
A. James M. Daveson, Robert P. Anderson, Michael P. Cooreman, Kaela E. Goldstein, James MacDougall, Leslie J. Williams, Tim King, Jane M. Andrews, Anita Treohan, John L. Dzuris, Hooi C. Ee
Publikováno v:
EBioMedicine
EBioMedicine, Vol 26, Iss C, Pp 78-90 (2017)
EBioMedicine, Vol 26, Iss C, Pp 78-90 (2017)
Background Nexvax2® is a novel, peptide-based, epitope-specific immunotherapy intended to be administered by regular injections at dose levels that increase the threshold for clinical reactivity to natural exposure to gluten and ultimately restore t
Autor:
Xinxin Zhang, Yan Zhu, Bin Li, Xiaoqing Jiang, Peizhan Chen, Shupeng Liu, Xuqian Fang, Jianming Zheng, Ming-Yu Zhu, Jialin Cai, Mingjie Wang
Publikováno v:
EBioMedicine
EBioMedicine, Vol 19, Iss C, Pp 18-30 (2017)
EBioMedicine, Vol 19, Iss C, Pp 18-30 (2017)
Many molecular classification and prognostic gene signatures for hepatocellular carcinoma (HCC) patients have been established based on genome-wide gene expression profiling; however, their generalizability is unclear. Herein, we systematically asses
Autor:
Carl Turesson, Maria Victoria Hernández, Karel Pavelka, Delphine S. Courvoisier, Deshire Alpizar-Rodriguez, Denis Choquette, J.-E. Gottenberg, Axel Finckh, Maria José Santos, Elisabeth Lie, Xavier Mariette, Merete Lund Hetland, Florenzo Iannone
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 302-306 (2016)
EBioMedicine
EBioMedicine, Vol. 11 (2016) pp. 302-306
EBioMedicine
EBioMedicine, Vol. 11 (2016) pp. 302-306
Background Response to disease modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) is often heterogeneous. We aimed to identify types of disease activity trajectories following the initiation of a new biologic DMARD (bDMARD). Methods
Autor:
Lambertus A. Kiemeney, Kai Uwe Saum, Heike Bickeböller, Erik H.F.M. van der Heijden, Philip Lazarus, Younghun Han, Timothy B. Baker, Bo Deng, Aage Haugen, Shen Chih Chang, Rayjean J. Hung, Loic Le Marchand, Margaret R. Spitz, Eric J. Duell, Helen M. Hansen, M. Dawn Teare, Amy C. Horton, Hendrik Dienemann, Li-Shiun Chen, Vidar Skaug, John K. Wiencke, Margaret Wrensch, Angeline S. Andrew, Eric O. Johnson, Penella J. Woll, Iona Cheng, John McLaughlin, Jose I. Mayordomo, Xifeng Wu, Mala Pande, Shanbeh Zienolddiny, Angela Risch, Nancy L. Saccone, Geoffrey Liu, Sarah M. Hartz, Claire H. Kim, Ann G. Schwartz, Ping Yang, Angela S. Wenzlaff, Albert Rosenberger, Janet Horsman, Robert Culverhouse, Dorothy K. Hatsukami, Zuo-Feng Zhang, Hermann Brenner, Irene Brüske, Jason A. Wampfler, Katja K.H. Aben, Laura J. Bierut, Christopher I. Amos
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 219-226 (2016)
Ebiomedicine, 11, pp. 219-226
EBioMedicine
EBioMedicine 11, 219-226 (2016)
Ebiomedicine, 11, 219-226
Ebiomedicine, 11, pp. 219-226
EBioMedicine
EBioMedicine 11, 219-226 (2016)
Ebiomedicine, 11, 219-226
Background Recent meta-analyses show that individuals with high risk variants in CHRNA5 on chromosome 15q25 are likely to develop lung cancer earlier than those with low-risk genotypes. The same high-risk genetic variants also predict nicotine depend
Autor:
Bai Zeng, Max Xiangtian Kong, Wen-Chi Chen, Gabriele Grunig, Betty Wang, Helen H Liu, Yunpeng Zhao, Fengxia Liang, Ying Chen, Wei Tang, Gerald L. Chan, Chuan-ju Liu, Qingyun Tian, Paola Torres, Gregory A. Grabowski, Gregory M. Pastores, Guilin Wang, Shuai Zhao, Rachel Saunders-Pullman, Herman S. Overkleeft, Jinlong Jian, Ying Sun
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 127-137 (2016)
EBioMedicine
EBioMedicine, 11, 127-137. Elsevier: Creative Commons / Elsevier
EBioMedicine
EBioMedicine, 11, 127-137. Elsevier: Creative Commons / Elsevier
Background Gaucher disease (GD) is a genetic disease caused by mutations in the GBA1 gene which result in reduced enzymatic activity of β-glucocerebrosidase (GCase). This study identified the progranulin (PGRN) gene (GRN) as another gene associated