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Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1
Autor:
Wen Jin, Xine Shi, Jessica C. Page, Shihuan Kuang, Naagarajan Narayanan, Yan Xiong, Tizhong Shan, Zhihao Jia, Feng Yue, Riyi Shi, Meng Deng, Gongshe Yang, Chao Wang, Keping Hu
Publikováno v:
EBioMedicine
EBioMedicine, Vol 24, Iss C, Pp 127-136 (2017)
EBioMedicine, Vol 24, Iss C, Pp 127-136 (2017)
Brown adipose tissues (BAT) burn lipids to generate heat through uncoupled respiration, thus representing a powerful target to counteract lipid accumulation and obesity. The tumor suppressor liver kinase b1 (Lkb1) is a key regulator of cellular energ
Autor:
Eldad A. Hod, Christopher A. Tormey, David R Gibb, Steven L. Spitalnik, Jeanne E. Hendrickson, Samuele Calabro, James C. Zimring, Dong Liu, Stephanie C. Eisenbarth
Publikováno v:
EBioMedicine
EBioMedicine, Vol 9, Iss C, Pp 77-86 (2016)
EBioMedicine, Vol 9, Iss C, Pp 77-86 (2016)
Red blood cell (RBC) transfusions are essential for patients with hematological disorders and bone marrow failure syndromes. Despite ABO matching, RBC transfusions can lead to production of alloantibodies against “minor” blood group antigens. Non
Publikováno v:
EBioMedicine.
Background Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases. Pro-inflammatory eicosanoids have been implicated in t
Autor:
Dave Singh
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1580-1581 (2015)
Neutrophils provide innate immune defence against microbes such as bacteria. Neutrophilic airway inflammation is a characteristic feature of chronic obstructive pulmonary disease (COPD) (Hogg et al., 2004), a condition that is commonly caused by ciga