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Autor:
Anudeep Yekula, Elizabeth Lansbury, Scott Mordecai, Fred H. Hochberg, Leonora Balaj, Bethany Delcuze, Julia L. Small, Pamela S. Jones, John Tigges, Alain Charest, Caroline M. Ayinon, Bob S. Carter, Ionita Ghiran
Publikováno v:
EBioMedicine, Vol 48, Iss, Pp 23-35 (2019)
EBioMedicine
EBioMedicine
Summary: Background: Malignant gliomas are rapidly progressive brain tumors with high mortality. Fluorescence guided surgery (FGS) with 5-aminolevulinic acid (5-ALA) provides fluorescent delineation of malignant tissue, which helps achieve maximum sa
Autor:
Belinda L. Sun, Xiaoguang Sun, Joe G.N. Garcia, Taylor Gregory, Amit M. Algotar, Sara M. Camp, Nancy Casanova, Alexander N. Garcia, Vivian Reyes Hernon, Radu C. Oita, Anne E. Cress
Publikováno v:
EBioMedicine, Vol 61, Iss, Pp 103059-(2020)
EBioMedicine
EBioMedicine
Background There remains a serious need to prevent the progression of invasive prostate cancer (PCa). We previously showed that secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) is a multifunctional innate immunity regulator via
Autor:
Jin Zhou, Yingmiao Liu, Yueyue Li, Peng Zhou, Xiaojing Chen, Jinming Zhang, Lixiu Wang, Yue Zhang, Haijiao Jing, Jialan Shi, Chunxu Wang, Jingwen Du, Muxin Yu, Baorong Li, Shaohong Fang, Valerie A. Novakovic, Yufeng Wang, Yiming Feng, Zengxiang Dong
Publikováno v:
EBioMedicine, Vol 60, Iss, Pp 102992-(2020)
EBioMedicine
EBioMedicine
Background The role of vascular endothelium in acute promyelocytic leukaemia (APL) remains unknown. We aimed to investigate the mechanisms by which APL cells interact with endothelial cells (ECs) and to further explore how the endothelium affects ble
Autor:
Zhitao Jing, Haiying Zhang, Dan Zou, Ye Zhang, Jiangfeng Hu, Dianqi Hou, Jinpeng Zhou, Junshuang Zhao, Long Li, Yang Jiang
Publikováno v:
EBioMedicine
EBioMedicine, Vol 52, Iss, Pp-(2020)
EBioMedicine, Vol 52, Iss, Pp-(2020)
Background: Glioma has a poor prognosis, and is the most common primary and lethal primary malignant tumor in the central nervous system. Retinoic acid receptor-related orphan receptor A (RORA) is a member of the ROR subfamily of orphan receptors and
Publikováno v:
EBioMedicine, Vol 34, Iss, Pp 61-75 (2018)
EBioMedicine
EBioMedicine
Background: Long non-coding (lnc) RNAs plays an important role in chronic myeloid leukemia (CML). In this study, we aimed to uncover the mechanism of the lncRNA maternally expressed 3 (MEG3) and its target microRNA-147 (miR-147) in CML. Methods: Sixt
Autor:
Jun Yokota, Curtis C. Harris, Motonobu Saito, Momoyo Nishida, Naoto Tsuchiya, Ana I. Robles, Masatoshi Watanabe, Takashi Kohno, Yuko Fujiwara, Takahiro Ochiya, Fumitaka Takeshita
Publikováno v:
EBioMedicine
Background Activation of intrinsic p53 tumor-suppressor (TS) pathways is an important principle underlying cancer chemotherapy. It is necessary to elucidate the precise regulatory mechanisms of these networks to create new treatment strategies. Metho