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Autor:
Amira Masri, Abdelkarim A. Al-Qudah, Maysa Suyagh, Yasmeen I. Dodin, Abdallah M. Younes, Ziad T. Nuseir, Salah AbuRuz, Mohammad Saleh, Mutasim Al-Ghazawi
Publikováno v:
Drug Research. 71:429-437
Aims To characterize the population pharmacokinetics of lamotrigine in Jordanian epileptic patients and to identify factors affecting therapeutic parameters. Patients and Methods A population pharmacokinetics model for lamotrigine was established bas
Publikováno v:
Drug Research. 71:157-165
The aim of this study is to investigate whether sitagliptin can be used as an initial drug for T2DM and to evaluate its effects on metabolic parameters in relation to its glycemic efficacies. The subjects received 25−50 mg/day sitagliptin monothera
Autor:
Jalal Hanaie, Javad Valipor, Ali Ostadi, Golriz Hosseini, Aliasghar Hamidi, Saeed Ghanbarzadeh
Publikováno v:
Drug Research. 71:193-198
Background Lead is a hazardous heavy metal, which causes many problems in the human body. Unfortunately, recent reports showed that smugglers and opium sellers add lead to drugs during the production procedure in order to increase its weight and cost
Autor:
Hanka de Voogd, Abdus Samad, Sigal Kaplan, Stella Böhmert, Shashank Jain, Rita Silveira Ramos, Mónika Domahidy, Thomas Körnicke, Deepa Arora
Publikováno v:
Drug Research. 70:472-477
Aim This study assessed the linearity of pharmacokinetics (PK) of trimetazidine (TMZ) modified-release tablets (indicated in adults as an add-on therapy for stable angina pectoris) and measured its renal elimination, safety, and tolerability in healt
Autor:
Samin Sabzevari, Seyed Mousa Taghavi, Razieh Keshavarz-Maleki, Amir Shadboorestan, Omid Sabzevari, Seyed Nasser Ostad, Maryam Gholami, Hossein Mozdarani
Publikováno v:
Drug Research. 70:360-366
Background: Green tea (Camellia sinensis), which is the most common drink across the world after water, has many antioxidant properties. Epigallocatecin-3-gallate (EGCG) is a flavonoid which accounts for 33–50% of green tea solids. It functions as
Autor:
Daisuke Maruoka, Yuichi Koike, Takahiro Nishimura, Hideaki Nagai, Koichiro Atsuda, Masahiro Kobayashi, Haruichi Kohno
Publikováno v:
Drug Research. 70:199-205
In Japan, tuberculosis has been recognized as one of the major infections requiring urgent measures because of its high morbidity rate even now especially in elderly people suffering from tuberculosis during the past epidemic and its reactivation. He
Autor:
Naveed Akhtar, Muhammad Usman Minhas, Kifayat Ullah Khan, Muhammad Imad-ud-din Zangi, M. Ahsan Shaker, Abubakar Munir
Publikováno v:
Drug Research. 70:158-164
Objectives In this communication we report an important findings, the effect of Al/Mg hydroxide antacid and food on the pharmacokinetics of dexibuprofen when administered concomitantly. Methods Subjects were divided into four groups, each containing
Publikováno v:
Drug Research. 70:170-173
In the last decade, a new direction of phototherapy – the non-selective chromotherapy (NSC) with Bioptron – has become widespread in clinical physiotherapy. The aim of the study was the scientific justification of the comprehensive treatment of p
Autor:
Mohammed Bouhajib, Zia Tayab
Publikováno v:
Drug Research. 70:33-40
Purpose Due to bioanalytical limitations it was previously not possible to evaluate the pharmacokinetics of dabigatran etexilate. We have developed validated methods to assay dabigatran etexilate, unconjugated dabigatran, and total dabigatran that wi
Autor:
Ahmad Al-Ghazawi, Nasir Idkaidek
Publikováno v:
Drug Research. 69:348-351
Pharmacokinetics of paracetamol (APAP) was studied on-board during an air flight and compared to those on ground after 500 mg oral dose in 20 healthy human volunteer in parallel design study. Saliva samples were obtained every 15 min up to 2 h after