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Publikováno v:
Drug Metabolism Reviews. 51:378-387
Lysergic acid diethylamide (LSD) is the most potent hallucinogen known and its pharmacological effect results from stimulation of central serotonin receptors (5-HT2). Since LSD is seen as physiologically safe compound with low toxicity, its use in th
Autor:
Ricardo Jorge Dinis-Oliveira
Publikováno v:
Drug metabolism reviews. 49(1)
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During the l
Publikováno v:
Drug metabolism reviews. 48(2)
Synthetic cathinones are commonly abused novel psychoactive substances (NPS). We present a comprehensive systematic review addressing in vitro and in vivo synthetic cathinone pharmacokinetics, analytical methods for detection and quantification in bi
Publikováno v:
Drug Metabolism Reviews. 42:55-61
The widely prescribed anticoagulant, Coumadin (racemic R/S-warfarin), Bristol-Myers Squibb Company, Clinton, NY has a narrow therapeutic range and wide interindividual response due, in part, to drug metabolism. Early identification of hydroxywarfarin
Autor:
Jack Uetrecht
Publikováno v:
Drug Metabolism Reviews. 38:745-753
Reactive metabolites are believed to be responsible for most idiosyncratic drug reactions. It is often assumed that if a reactive metabolite is found, it must be responsible for the idiosyncratic reactions associated with that drug. However, the evid
Autor:
Gisèle Pickering, Lizi Zhao
Publikováno v:
Drug metabolism reviews. 43(1)
Paracetamol (acetaminophen) is a worldwide used analgesic and antipyretic drug. It is metabolised via several metabolic pathways, including glucuronidation, sulfation, oxidation, hydroxylation, and deacetylation: Hepatic and other organ damage may oc
Publikováno v:
Drug metabolism reviews. 30(4)
(1998). Metabolism of Haloperidol and Its Tetrahydropyridine Dehydration Product HPTP. Drug Metabolism Reviews: Vol. 30, No. 4, pp. 809-826.
Publikováno v:
ResearcherID
Autor:
J. L. Holtzman
Publikováno v:
Drug metabolism reviews. 27(1-2)
(1995). The Role of Covalent Binding to Microsomal Proteins in the Hepatotoxicity of Acetaminophen. Drug Metabolism Reviews: Vol. 27, No. 1-2, pp. 277-297.
Autor:
Sidney D. Nelson
Publikováno v:
Drug metabolism reviews. 27(1-2)
Acetaminophen and pulegone are just two examples for many agents that can form reactive metabolites that can cause acute liver injury. Two other classic organic compounds that have been extensively studied are carbon tetrachloride (for a recent revie