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Autor:
Luiz Fernando Freire Royes, Micheli Dassi, Michele Rechia Fighera, Marcel Henrique Marcondes Sari, Ana Flávia Furian, Ana Cláudia Monteiro Braga, Érica Vanessa Furlan Rosa, Naieli Schiefelbein Souto, Mauro Schneider Oliveira
Publikováno v:
Drug and Chemical Toxicology. 45:2780-2785
The potential interactions among food additives/contaminants and the consequences to biological systems is a topic that is rarely addressed in scientific literature. Thus, the current study investigated if the combined administration of ASP and AFB1
Publikováno v:
Drug and Chemical Toxicology. 45:2678-2685
Methotrexate is an important immunosuppressive and antineoplastic drug and is widely used for treatment. However, hepatotoxicity is one of the major adverse effects of methotrexate. In this study, it was aimed to investigate whether ramelteon has a p
Autor:
Abdulahad Dogan, Fatih Donmez
Publikováno v:
Drug and Chemical Toxicology. 45:2686-2698
Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixicacid. FQs are used against SARS-CoV-2 in our country, and for the treatment of some urinary tract diseases, gastrointestinal diseases, respiratory tract
Autor:
Moncef Fekih, Emna Gaïes, Hammami Mohamed Bassem, Ridha Ben Ali, Michelle-Véronique Elmay, Israa Dahmani, Sihem El Aïdli, Dorra Ben Said, Achraf Chedly
Publikováno v:
Drug and Chemical Toxicology. 45:2594-2600
Isoniazid (INH), being the first-line drug used as an anti-tuberculosis drug, is known to be associated with physiological deteriorations including hepatic and neurologic disturbances. This study was aimed at biochemical and behavioral characterizati
Publikováno v:
Drug and Chemical Toxicology. 45:2568-2575
Gentamicin (GM) is an antibiotic belonging to an aminoglycoside family that might induce nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) are part of innat...
Publikováno v:
Drug and Chemical Toxicology. 45:2554-2560
Acute toxicity of organophosphorus compounds is primarily caused by inhibition of acetylcholinesterase (AChE) at cholinergic synapses. The current study was designed to investigate the effects of paraoxon on histological changes as well as the role o
Publikováno v:
Drug and Chemical Toxicology. 45:2448-2453
Tungsten (W) and its compounds have emerged as a relatively new area of environmental health concern in the last decade. Tungsten is environmentally benign due to its increasing use in armour-piercing munitions and as a replacement for lead in other
Publikováno v:
Drug and Chemical Toxicology. 45:2483-2487
The deficiency of essential minerals increases lead absorption and thus aggravates the lead-induced toxic effects. This study was aimed at understanding the ameliorative effect of essential minerals on lead-induced alterations in hematological parame
Publikováno v:
Drug and Chemical Toxicology. 45:2463-2470
The present study aimed to investigate the protective role of capsaicin in a rat model of 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced toxicity. Exposure to TCDD which is an environmental toxicant causes severe toxic effects in the animal and
Publikováno v:
Drug and Chemical Toxicology. 45:2185-2192
Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that potent, centra