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Publikováno v:
Drug and Chemical Toxicology. 45:2678-2685
Methotrexate is an important immunosuppressive and antineoplastic drug and is widely used for treatment. However, hepatotoxicity is one of the major adverse effects of methotrexate. In this study, it was aimed to investigate whether ramelteon has a p
Autor:
Abdulahad Dogan, Fatih Donmez
Publikováno v:
Drug and Chemical Toxicology. 45:2686-2698
Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixicacid. FQs are used against SARS-CoV-2 in our country, and for the treatment of some urinary tract diseases, gastrointestinal diseases, respiratory tract
Autor:
Moncef Fekih, Emna Gaïes, Hammami Mohamed Bassem, Ridha Ben Ali, Michelle-Véronique Elmay, Israa Dahmani, Sihem El Aïdli, Dorra Ben Said, Achraf Chedly
Publikováno v:
Drug and Chemical Toxicology. 45:2594-2600
Isoniazid (INH), being the first-line drug used as an anti-tuberculosis drug, is known to be associated with physiological deteriorations including hepatic and neurologic disturbances. This study was aimed at biochemical and behavioral characterizati
Publikováno v:
Drug and Chemical Toxicology. 45:2568-2575
Gentamicin (GM) is an antibiotic belonging to an aminoglycoside family that might induce nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) are part of innat...
Publikováno v:
Drug and Chemical Toxicology. 45:2554-2560
Acute toxicity of organophosphorus compounds is primarily caused by inhibition of acetylcholinesterase (AChE) at cholinergic synapses. The current study was designed to investigate the effects of paraoxon on histological changes as well as the role o
Publikováno v:
Drug and Chemical Toxicology. 45:2185-2192
Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that potent, centra
Treatment with human umbilical cord blood serum in a gentamicin-induced nephrotoxicity model in rats
Publikováno v:
Drug and Chemical Toxicology. 45:2262-2268
Sold under the brand name of Garamycin, gentamicin (GM) is an antibiotic in the category of aminoglycoside, that although does have many antibacterial properties, owing to several side effects, its consumption is confined. The current study is aimed
Autor:
Cibele dos Santos Borges, Katiussia Pinho da Silva, André S. Pupo, Patrícia Villela e Silva, Andre Mueller, Lethícia Valencise, Gustavo Venâncio da Silva, Jorge Willian Franco de Barros, Wilma De Grava Kempinas
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2021-06-25T11:15:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Statins are 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitor drugs that lead to serum-cholesterol-lowering effects. Rosuvastatin
Publikováno v:
Drug and Chemical Toxicology. 45:2160-2168
Aim Although the most common age-related neurodegenerative disease defined by memory loss is Alzheimer's disease (AD), only symptomatic therapies are present. A complex pathway for the AD pathogenesis that includes an increase in inflammation has rec
Publikováno v:
Drug and Chemical Toxicology. 45:2024-2030
The aim of the present study was to investigate the therapeutic and protective effects of linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were divided into 8 groups as follows; Control, DOX [20 mg/kg, intraperitoneal