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Publikováno v:
Drug and Chemical Toxicology. 41:287-293
Diazinon (Dz) is a widely used insecticide. It can induce nephrotoxicity and neurotoxicity via oxidative stress. Captopril, an angiotensin-converting enzyme inhibitor, is known for its antioxidant properties. In this study, we used captopril for amel
Autor:
Jan Misik, Marketa Krejciova, Jana Zdarova Karasova, Jan Korabecny, Ondrej Soukup, Milos Hroch, Ladislav Novotny, Kamil Kuca, Vendula Hepnarova, Martina Hrabinova
Publikováno v:
Drug and chemical toxicology. 44(2)
The search for tacrine derivatives, as potential Alzheimer´s disease treatment, is still being at the forefront of scientific efforts. 7-MEOTA was found to be a potent, centrally active acetylcholinesterase inhibitor free of the serious side effects
Publikováno v:
Drug and chemical toxicology. 44(4)
Metformin is widely used as an oral hypoglycemic drug in the management of type 2 diabetes mellitus. This study evaluated the possible protective effects of metformin against cisplatin-induced genotoxicity and apoptosis in rat bone marrow cells. Two
Publikováno v:
Drug and chemical toxicology. 44(4)
Cisplatin has been widely used as an anticancer agent for a wide range of tumors, but it had nephrotoxicity that was mainly caused by oxidative stress. Edaravone, a free radical scavenger, has reportedly been validated to have a protective effect aga
Publikováno v:
Drug and chemical toxicology. 43(1)
Vancomycin (VCM), a glycopeptide antibiotic, is a drug widely used in severe infections. However, VCM induce notable nephrotoxic side effects. Naringenin (NAR) is a natural of flavonoid and are known as strongly antioxidant, nefroprotective, antiapop
Publikováno v:
Drug and chemical toxicology. 43(5)
Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the admini
Publikováno v:
Drug and chemical toxicology. 42(2)
The present study is conducted to evaluate the neuroprotective effect of curcumin nanoparticles (CUR NP) against the neurotoxicity induced by cisplatin (CP) in rat. Rats were divided into control group that received saline solution, CP-treated rats t
Publikováno v:
Drug and chemical toxicology. 42(1)
Cisplatin (CP) is a major antineoplastic drug for the treatment of solid tumors, however, its clinical utility is limited by nephrotoxicity. Also, radiotherapy is an important treatment modality for many malignancies. The present studies were perform
Autor:
Mousa-Al-Reza Hadjzadeh, Zeinab Ashaari, Farimah Beheshti, Roghayeh Pakdel, Soleyman Bafadam, Mahmoud Hosseini, Kowsar Bavarsad
Publikováno v:
Drug and chemical toxicology. 43(1)
The effect of levothyroxine (L-T4) on the learning and memory impairment induced by streptozotocin (STZ) and brain tissue oxidative damage in rats was evaluated. An animal model of the Alzheimer's disease (AD) was established by intracerebroventricul
Publikováno v:
Drug and chemical toxicology. 41(3)
Estrogen-progestin oral contraceptives (COC) or tobacco smoking has been associated with hypertension and endothelial dysfunction resulting in increased risk of cardiovascular diseases (CVD). Contrasting effects of nicotine exposure on endothelial fu