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Publikováno v:
Drug and Chemical Toxicology. 45:2554-2560
Acute toxicity of organophosphorus compounds is primarily caused by inhibition of acetylcholinesterase (AChE) at cholinergic synapses. The current study was designed to investigate the effects of paraoxon on histological changes as well as the role o
Publikováno v:
Drug and Chemical Toxicology. 45:393-397
Chemotherapy-induced peripheral neuropathy has an important impact on the quality of life of cancer patients. Vincristine-induced neuropathy is a major dose-limiting side effect. Symptoms of peripheral neuropathy are spontaneous pain, allodynia, and
Autor:
Anna Sznejder-Pachołek, Justyna Pyrzanowska, Dagmara Mirowska-Guzel, Ewa Widy-Tyszkiewicz, Ilona Joniec-Maciejak, Agnieszka Piechal, Kamilla Blecharz-Klin, Adriana Wawer
Publikováno v:
Drug and chemical toxicology. 45(4)
In this study, we investigated the effects of early paracetamol treatment on the testicular level of testosterone and expression of genes important for steroid biosynthesis and reproduction in male rats offspring. Rats were continuously exposed to pa
Autor:
Ilias Marmouzi, Sihame Ouakki, Abdelhalem Mesfioui, Aboubaker El Hessni, Ali Ouichou, Oussama Zghari, Sofia Azirar, Mouloud Lamtai, Inssaf Berkiks
Publikováno v:
Drug and chemical toxicology. 45(4)
Copper (Cu) is a heavy metal with the ability to induce, at high levels, neurobehavioral alterations, and oxidative stress (OS). On the other hand, melatonin (Mel) is a neurohormone that protects neurons from OS and has a modulatory effect on several
Publikováno v:
Drug and chemical toxicology. 45(3)
Oxidative stress and mitochondrial dysfunction have been associated with valproic acid (VPA) induced neurotoxicity. Mitochondria are vulnerable to oxidative damage and are also a major source of superoxide free radicals. Therefore, the need for mitoc
Publikováno v:
Drug and chemical toxicology. 45(3)
Here, we studied the protective effect of rutin (RUT) against testicular damage caused by busulfan (BUS) in rats. Adult male Wistar rats were intraperitoneally injected with BUS (4 mg/kg body weight at day 7 and 14), and then treated with RUT (30 mg/
Publikováno v:
Drug and chemical toxicology. 45(2)
Dexamethasone (DEX) is used for various conditions in female and even during pregnancy. We tested the hypothesis that DEX exposure in female rats would lead to renal free fatty acid (FFA) accumulation with elevated xanthine oxidase (XO) activity that
Publikováno v:
Drug and chemical toxicology. 43(5)
Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the admini
Autor:
Mousa-Al-Reza Hadjzadeh, Zeinab Ashaari, Farimah Beheshti, Roghayeh Pakdel, Soleyman Bafadam, Mahmoud Hosseini, Kowsar Bavarsad
Publikováno v:
Drug and chemical toxicology. 43(1)
The effect of levothyroxine (L-T4) on the learning and memory impairment induced by streptozotocin (STZ) and brain tissue oxidative damage in rats was evaluated. An animal model of the Alzheimer's disease (AD) was established by intracerebroventricul
Publikováno v:
Drug and chemical toxicology. 41(3)
Estrogen-progestin oral contraceptives (COC) or tobacco smoking has been associated with hypertension and endothelial dysfunction resulting in increased risk of cardiovascular diseases (CVD). Contrasting effects of nicotine exposure on endothelial fu