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Publikováno v:
Drug and chemical toxicology. 45(3)
Here, we studied the protective effect of rutin (RUT) against testicular damage caused by busulfan (BUS) in rats. Adult male Wistar rats were intraperitoneally injected with BUS (4 mg/kg body weight at day 7 and 14), and then treated with RUT (30 mg/
Autor:
Sung Tae Kim, Ji Hoon Jeong, Jun Ho Lee, Tae Jin Lee, Eun Jung Kyung, Ho Sung Lee, Won Mo Lee, Eon Sub Park, Soo In Chae, Jung Sook Suh, Jinhyung Bae, Yoon Hee Chung, Uy Dong Sohn
Publikováno v:
Drug and Chemical Toxicology. 41:476-485
Docetaxel is a taxane chemotherapeutic agent used in the treatment of breast cancer, prostate cancer and gastric cancer, but several side effects such as peripheral neurotoxicity could occur. The present study was designed to investigate the therapeu
Publikováno v:
Drug and Chemical Toxicology. 36:263-269
The toxicity of amiodarone Lek formulation (test formulation) was investigated after a single intravenous (i.v.) administration to mice and rats. When compared to the reference item, Cordarone (Cordarone(®); Wyeth Pharmaceuticals Inc., Collegeville,
Autor:
Zuraini Ahmad, Azhar Yaacob, N. Somchit, Arifah Abdul Kadir, Jun Hung Chung, Zainul Amiruddin Zakaria
Publikováno v:
Drug and Chemical Toxicology. 35:304-309
Voriconazole is a new, potent broad-spectrum triazole systemic antifungal drug, a second-generation azole antifungal that is increasing in popularity, especially for the treatment of invasive aspergillosis and fluconazole-resistant invasive Candida i
Publikováno v:
Drug and Chemical Toxicology. 34:101-108
The aim of this study was to investigate the protective action of licorice in diabetic nephropathy in male rats. Diabetes was induced in male Wistar rats by using streptozotocin (60 mg/kg body weight). Daily oral ingestion (1 g/kg body weight) of lic
Publikováno v:
Drug and Chemical Toxicology. 33:410-414
Celecoxib is intended for acute pain, menstrual cramps, pain, and inflammation of osteoarthritis and rheumatoid arthritis. The aim of this study was to evaluate the effects of celecoxib (10 and 50 mg/kg/day) treatment on rats orally for 28 days. We e
Publikováno v:
Drug and Chemical Toxicology. 33:261-268
It has been asserted that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases the risk for diabetes mellitus in humans, observable as hyperglycemia resulting from insulin resistance. There is no animal model for the induction of diabetes
Publikováno v:
Drug and Chemical Toxicology. 33:209-216
The effect of melatonin on the neurotoxicity induced by mercuric chloride was studied. Adult rats were fed orally with two different doses of mercuric chloride (2 mg; 4 mg/kg body weight) to evaluate brain toxicity with respect to cerebral hemisphere
Publikováno v:
Drug and Chemical Toxicology. 28:423-432
Miglyol 812 is a medium-chain triglyceride used in toxicology studies as an excipient to improve test compound solubility/absorption. As part of a larger toxicology study, 15 Wistar Han IGS rats/sex/group were dosed by oral gavage for 4 weeks with 10
Publikováno v:
Drug and Chemical Toxicology. 28:409-421
Aspirin (ASA), an irreversible cyclooxygenase (COX) inhibitor, induces ventricular septal defect (VSD) and diaphragmatic hernia (DH) in rat fetuses when administered on gestation days (GDs) 9-10, a critical period for cardiovascular (CV) and midline