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Publikováno v:
Drug and Alcohol Dependence. 29:69-75
Behavioural and physiological indices which could be symptoms of individual Wistar rats' sensitivity to the development of physical dependence on morphine, were studied. This state was induced in three different ways: (l)by i.p. injection of increasi
Publikováno v:
Drug and Alcohol Dependence. 28:129-144
Male rats were injected with ethanol (groups 3 and 5; 2.0 g/kg i.p.) or saline (groups 2 and 4) once a week for 52 weeks. The rats had access to ethanol as a voluntary choice for 24 h either once 6 days after the injection (groups 2 and 3) or twice 3
Autor:
S.Y. Yeh, E B De Souza
Publikováno v:
Drug and Alcohol Dependence. 27:51-61
Rats were injected with cocaine (20 mg/kg, s.c. or i.p. twice daily for 8 days) or saline and killed at 1, 8, 15 or 48 days after the last injection. The concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and their metabolites, as
Publikováno v:
Drug and Alcohol Dependence. 25:67-71
The effect of chronic ethanol consumption on plasma and erythrocyte membrane lipids were studied in rats fed a liquid diet containing ethanol for 4 weeks and intubated with the same diet 90 min prior to killing. Control animals underwent the same tre
Autor:
Klaus Opitz
Publikováno v:
Drug and Alcohol Dependence. 25:43-48
Clonidine, guanfacine and tiamenidine, in equihypotensive doses, significantly reduced alcohol intake in ethanol-preferring rats having free choice between 10% ethanol and drinking water. Water intake was only slightly reduced, especially during the
Publikováno v:
Drug and alcohol dependence. 77(3)
Sufficient evidence exists for the inclusion of the ventral pallidum (VP) into the category of a dopaminoceptive brain region. The effects of inhibiting dopamine D(1)- or D(2)-like receptors in the VP on (a) ethanol intake and (b) extracellular level
Autor:
Richard P. Michael, Gerald J. Schaefer
Publikováno v:
Drug and alcohol dependence. 30(1)
These studies were aimed at investigating interactions between alcohol and nicotine on operant behavior and on locomotor activity. Independent groups of rats with electrodes in the lateral hypothalamus were trained to lever press for intracranial sel
Publikováno v:
Drug and alcohol dependence. 30(1)
Ethanol is known to decrease the quantity of polyunsaturated fatty acids in brain membranes possibly as the repercussion of an inhibition of delta-5- and delta-6-desaturases. Consequently behavioural changes may occur. Evening Primrose Oil (EPO) whic
Autor:
Barbara Przewlocka, Władysław Lasoń
Publikováno v:
Drug and alcohol dependence. 27(1)
The effect of ethanol administration on the in vitro release of alpha-neoendorphin (ANEO) and Met-enkephalin-Arg6-Gly7-Leu8 (MEAGL), peptides derived from prodynorphin and proenkephalin, respectively, was studied in the rat hypothalamus. Single ethan
Publikováno v:
Drug and alcohol dependence. 27(1)
This paper reports data on the effect of two drugs: Heparegen (thiazalidine-4-carboxylic acid) and D-penicillamine on the blood ammonia concentration and on some ammonia metabolizing enzymes in liver and brain of rats intoxicated with ethanol. It see