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Publikováno v:
Drug and Alcohol Dependence. 29:69-75
Behavioural and physiological indices which could be symptoms of individual Wistar rats' sensitivity to the development of physical dependence on morphine, were studied. This state was induced in three different ways: (l)by i.p. injection of increasi
Autor:
Helmut Coper, Ute-Angelika Jänicke
Publikováno v:
Drug and Alcohol Dependence. 13:177-189
The drinking behavior of naive rats changes predictably in a free choice experiment involving water vs. 0.02%, 0.01% and 0.003% (+)-amphetamine solutions: The higher the concentration of the amphetamine solution, the sooner a number of rats quit drin
Autor:
C.P. Manik, R.J. Katz
Publikováno v:
Drug and Alcohol Dependence. 13:311-314
Autor:
Per-Erik Björklund, Gunnar Tiger, Olle Magnusson, Trevor Archer, Agneta Nordberg, Göran Wahlström, Anders Stenström, Abdul K. Mohammed, Christopher J. Fowler
Publikováno v:
Drug and Alcohol Dependence. 20:203-212
Rats were tested for place learning in the Morris swim maze on days 110 –114 of abstinence following 48 weeks of treatment with sodium barbital. A retarded acquisition of the swim-maze task, that could not be ascribed to motor impairments, was foun
Autor:
Richard M. Eisenberg
Publikováno v:
Drug and Alcohol Dependence. 15:375-381
The present study examines the severity of naloxone-precipitated opiate withdrawal in morphine-pelleted rats and mice. Animals were chronically pretreated with either saline, diazepam, phenobarbital or amphetamine for 8 days prior to withdrawal preci
Autor:
Alicja Kruszewska, Romuald Langwiński
Publikováno v:
Drug and Alcohol Dependence. 12:273-278
It was found that 200 mg/kg of DL-p-chlorophenylalanine (PCPA) and 2 mg/kg of methergoline drugs inhibiting central serotoninergic transmission-decreased naloxone precipitated abstinence wet dog shakes in morphine-dependent rats. The inhibitory effec
Autor:
G. de Groot, J.W. van der Laan
Publikováno v:
Drug and Alcohol Dependence. 22:133-140
The anti-withdrawal action of clonidine was studied in a model of spontaneous morphine withdrawal in rats. After withdrawal the behaviour of the animals was registered continuously for several days. In the initial phase of induction of dependence the
Publikováno v:
Drug and Alcohol Dependence. 18:349-353
The formation of tolerance to the hypothermic effect of ethanol was inhibited in rats after intraperitoneal injection of the neurotoxin DSP-4 50 mg/kg. The neurotoxin also significantly suppressed the ethanol withdrawal syndrome; hyperlocomotion, aud
Autor:
Olgierd Pucilowski, Ewa Trzaskowska, Pawel Krza̧ścik, Wojciech Kostowski, Adelajda Staniszewska
Publikováno v:
Drug and Alcohol Dependence. 24:265-267
Bromocriptine, a mixed D-1/D-2 dopaminergic receptor agonist and SKF 38393, a D-1 specific agonist were found to alleviate the incidence and intensity of audiogenic convulsions in ethanol withdrawn rats. (+) and (-)3-PPP, putative D-2 autoreceptor ag
Autor:
Jolanta Kotlinska, Langwiński R
Publikováno v:
Drug and alcohol dependence. 18(4)
In rats the influence of the delta opioid agonists [Leu]enkephalin, [D-Ala2-D-Leu5]enkephalin, [D-Ala2]methionine enkephalinamide and synthetic analogue of [Met]enkephalin: Tyr-D-Ala-Gly-Phe-D-Leu-OMe on audiogenic seizures was tested during ethanol