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Publikováno v:
Drug and Alcohol Dependence. 28:129-144
Male rats were injected with ethanol (groups 3 and 5; 2.0 g/kg i.p.) or saline (groups 2 and 4) once a week for 52 weeks. The rats had access to ethanol as a voluntary choice for 24 h either once 6 days after the injection (groups 2 and 3) or twice 3
Publikováno v:
Drug and Alcohol Dependence. 17:37-45
The effects of subchronic nicotine treatment on the development of tolerance and on two nicotinic ligand binding sites were investigated. After subcutaneous injection of nicotine (0.45 mg nicotine base/kg) or saline twice a day for 14 days the body w
Autor:
Richard M. Eisenberg
Publikováno v:
Drug and Alcohol Dependence. 15:375-381
The present study examines the severity of naloxone-precipitated opiate withdrawal in morphine-pelleted rats and mice. Animals were chronically pretreated with either saline, diazepam, phenobarbital or amphetamine for 8 days prior to withdrawal preci
Publikováno v:
Drug and Alcohol Dependence. 18:349-353
The formation of tolerance to the hypothermic effect of ethanol was inhibited in rats after intraperitoneal injection of the neurotoxin DSP-4 50 mg/kg. The neurotoxin also significantly suppressed the ethanol withdrawal syndrome; hyperlocomotion, aud
Autor:
G.D. Nadkarni, Nympha B. D'Souza
Publikováno v:
Drug and alcohol dependence. 22(1-2)
In rats given ethanol 20% (v/v) in drinking water the hepatic antioxidant enzymes, Superoxide dismutase (SOD), catalase and glutathione peroxidase were assayed at the end of 4 and 10 months of ethanol consumption. Simultaneously hepatic lipid peroxid
Autor:
Christopher J. Fowler, Olle Magnusson, Anders Stenström, Agneta Nordberg, Gunnar Tiger, Cora O'Neill, Göran Wahlström
Publikováno v:
Drug and alcohol dependence. 22(1-2)
Male rats were treated with one ethanol (2.0 g/kg i.p.) or saline injections once a week for 50 weeks. During this treatment period the rats had in addition access to ethanol (10% in drinking fluid) as a choice against water for 24 h prior to the inj