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Autor:
J. Steven Richardson, Emma O. Lew
Publikováno v:
Drug and Alcohol Dependence. 8:93-101
A single dose of Δ 9 -tetrahydrocannabinol (THC) (10 or 100 mg/kg) was administered via stomach gavage following the single injection intraperitoneally of an acute dose of amphetamine (1 or 3 mg/kg) in the rat. The THC effects, which included a redu
Autor:
Romuald Langwiński, Alicja Kruszewska
Publikováno v:
Drug and Alcohol Dependence. 11:383-388
It was found that pimozide, haloperidol and α -methyl- p -tyrosine (α-MT), drugs inhibiting central catecholaminergic (CA) transmission, increased the development of morphine dependence measured as wet dog shakes in rats. Reserpine inhibiting CA an
Publikováno v:
Drug and Alcohol Dependence. 22:223-233
Oral administration of 5 mg/kg of d -amphetamine to adult Wistar rats caused brain NE to decrease to approx. 80% of the control level during 4–24 h after acute treatment and slowly further to 65% after 24 days of self-administration via drinking wa
Publikováno v:
Drug and Alcohol Dependence. 12:233-242
The effect of the opioid levorphanol on locomotor activity was investigated in rats treated with p-chlorophenylalanine (PCPA) or 6-hydroxydopamine (6-OHDA). Acute oral administration of 10 or 30 mg/kg levorphanol induces a time- and dose-dependent al
Publikováno v:
Drug and alcohol dependence. 22(3)
In rats treated with a thiamine deficient diet for 30 days the brain content of total thiamine decreased by 27–50%. Thiamine deficiency decreased the dopamine (DA) concentration of the striatum indicating a reduced synthesis of DA. In the hypothala
Publikováno v:
Drug and alcohol dependence. 15(3)
Two groups of rats were implanted with ALZET minipumps to deliver vehicle or a theoretical amount of 1 mg/kg per h of d-amphetamine (A) for 12 days. After 3 days of A-exposure, motor movements and stereotypic behavior were markedly increased. Subsequ