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pro vyhledávání: '"Thomas H. Gillingwater"'
Autor:
Thomas Becker, Thomas H. Gillingwater, Helena Chaytow, Catherina G. Becker, Neil O. Carragher, Hannah L. Smith, Ana-Maria Oprişoreanu, Sophia Krix
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Oprişoreanu, A, Smith, H L, Krix, S, Chaytow, H, Carragher, N O, Gillingwater, T H, Becker, C G & Becker, T 2021, ' Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy ', Disease Models and Mechanisms, vol. 14, no. 4 . https://doi.org/10.1242/dmm.047761
article-version (VoR) Version of Record
Oprişoreanu, A, Smith, H L, Krix, S, Chaytow, H, Carragher, N O, Gillingwater, T H, Becker, C G & Becker, T 2021, ' Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy ', Disease Models and Mechanisms, vol. 14, no. 4 . https://doi.org/10.1242/dmm.047761
Synapses are particularly vulnerable in many neurodegenerative diseases and often the first to degenerate, for example in the motor neuron disease spinal muscular atrophy (SMA). Compounds that can counteract synaptic destabilisation are rare. Here, w
Autor:
Saul, Herranz-Martin, Jayanth, Chandran, Katherine, Lewis, Padraig, Mulcahy, Adrian, Higginbottom, Callum, Walker, Isabel Martinez-Pena Y, Valenzuela, Ross A, Jones, Ian, Coldicott, Tommaso, Iannitti, Mohammed, Akaaboune, Sherif F, El-Khamisy, Thomas H, Gillingwater, Pamela J, Shaw, Mimoun, Azzouz
Publikováno v:
Disease Models & Mechanisms
Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified