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Autor:
Toshio Hashimoto, Mitsuhiro Yano, Tsukasa Fujishima, Shingo Kimura, Rintaro Ohe, Mitsunori Yamakawa, Naing Ye Aung, Wataru Kimura
Publikováno v:
Digestion. 101:401-410
Background: Many cancers express heme oxygenase-1 (HO-1) at a higher frequency than healthy tissues, and this elevated expression is associated with cancer prognosis. Here, we aim to clarify the correlation between HO-1-expressing macrophage number
Autor:
Noriko Sasahara, Hiroyuki Mitomi, Yoichi Akazawa, Sumio Watanabe, Takashi Yao, Yuzuru Tajima, Takashi Murakami, Tsuyoshi Saito, Takafumi Hiromoto
Publikováno v:
Digestion. 96:81-91
Background/Aims: Gastric adenocarcinoma of fundic gland type (GAFG), which is a rare variant of gastric cancer, is reportedly associated with both Wnt/β-catenin signaling activation and guanine nucleotide binding protein, alpha stimulating complex (
Autor:
Bentz S., Cee A., Endlicher E., Wojtal K. A., Naami A., Pesch T., Lang S., Schubert P., Fried M., Weber A., Coy J. F., Goelder S., Knüchel R., Hausmann M., Rogler G.
Publikováno v:
Digestion
Background and Aims: Transketolase-like (TKTL) 1 is one of the key enzymes for anaerobic sugar degradation even in the presence of oxygen (aerobic glycolysis). Transketolase-dependent reactions supply malignant tumors with ribose and NADPH. Therefore
Publikováno v:
Digestion. 82:179-186
Aims: To clarify the possible significance of increased expression of DNA methyltransferase (DNMT)-1 in the tumorigenesis of colorectal neoplasia in ulcerative colitis (UC) and to clarify whether analysis of DNMT1 expression in non-neoplastic epithel
Autor:
Yasumasa Niwa, Takafumi Ando, Motofusa Hasegawa, Nobuyuki Miyake, Makoto Tomita, Hidemi Goto, Masaaki Minami, Tsuyoshi Kato, Kazuhiro Ishiguro, Ryoji Miyahara, Naoki Ohmiya, Shinya Kondo, Osamu Watanabe
Publikováno v:
Digestion. 79:23-29
Background/Aims: Matrix metalloproteinases (MMPs) are endopeptidases which perform important functions in extracellular matrix remodeling, cell proliferation, and inflammatory processes. Here, we compared MMP-3 levels with those of tissue inhibitor o
Autor:
Chi Hin Cho, Benjamin C.Y. Wong, Harry Hua-Xiang Xia, Asif Rashid, Shiu Kum Lam, Li Ping Tang, Kent Man Chu, Wai Mo Hui, Annie On-On Chan, Camy Huang
Publikováno v:
Digestion. 74:85-90
Background: Both serum IL-6 levels and CpG island methylation have been shown to have prognostic significance in gastric cancer, it was suggested that an important link existed between IL-6 and methylation of cancers. Aim: To investigate the prognost
Autor:
Karl-Heinz Herzig, Frank Schmitz, Toshikazu Nakamura, Piotr Krokowicz, Karlheinz Kiehne, Hans U. Stechele, Ulrich R. Fölsch, Tomas Banasiewicz, Jan-Michel Otte
Publikováno v:
Digestion. 61:237-246
Background: Hepatocyte growth factor (HGF) stimulates proliferation, migration and morphogenesis of epithelial cells by specific binding to its receptor c-met. Overexpression of HGF or c-met has been reported for human gastric or pancreatic cancer. I