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Publikováno v:
Diagnostic Pathology
Background: The histopathological subtype, nuclear grade and presence or absence of comedonecrosis are established as critical elements in the reporting of ductal carcinoma in situ (DCIS) of the breast. The aims of this study were to determine the fr
Publikováno v:
Diagnostic Pathology
Background The different expression level of Dickkopf-1 (DKK-1) in different cancers shows that the function of DKK-1 depends on the histological type of the cancer cells and the tissue microenvironment. To our knowledge, the serum expression level o
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 6, Iss 1, p 74 (2011)
Diagnostic Pathology, Vol 6, Iss 1, p 74 (2011)
Background Using new molecular biology techniques, recent studies have implicated a common evolutionary pathway between lobular neoplasia, lobular carcinomas, and columnar cell lesions. Our aims were to assess the frequency of lobular neoplasia in a
Autor:
Ghadeer A Mokhtar, Samia Al Amoudi, Rana Y. Bokhary, Zuhoor K Al-Gaithy, Najlaa Bin Mahfouz, Eman Emam, Fadwa J. Altaf
Publikováno v:
Diagnostic Pathology
Background Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of metaplastic breast carcinoma and
Autor:
Claudio Eccher, Mattia Barbareschi, Silvia Fasanella, Luca Morelli, D. Aldovini, F. Gasperetti, Gabriella Berlanda, E. Leonardi, Emma Bragantini, I Bazzanella, Lucia Veronica Cuorvo, P. Dalla Palma, Antonella Ferro, Chiara Cantaloni
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 6, Iss Suppl 1, p S7 (2011)
Diagnostic Pathology, Vol 6, Iss Suppl 1, p S7 (2011)
Background Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation. Aim To test the
Publikováno v:
Diagnostic Pathology
Background Breast cancer is a heterogeneous disease consisting of different subtypes. Trichorhinophalangeal syndrome type 1 (TRPS1) gene, a GATA-type transcription factor, has been found to be highly expressed in breast cancer. Epithelial-to-mesenchy
Autor:
Nermeen S Youssef, Sarah A Hakim
Publikováno v:
Diagnostic Pathology
Background The effects of fascin on cell invasiveness involve changes in cell motility and matrix metalloproteinase-9 (MMP-9) activity. Previous studies on the prognostic value of fascin and MMP-9 in breast carcinoma revealed conflicting results. To
Publikováno v:
Diagnostic Pathology, Vol 6, Iss 1, p 18 (2011)
Diagnostic Pathology
Diagnostic Pathology
Background/Objective While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. Ax
Autor:
Jiri Navratil, Martina Rédová, Marek Svoboda, Markéta Palácová, Rostislav Vyzula, Ondrej Slaby, Jiri Sana, Pavel Fabian
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 7, Iss 1, p 31 (2012)
Diagnostic Pathology, Vol 7, Iss 1, p 31 (2012)
Background Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) represents the major phenotype of basal-like molecular subtype of breast cancer, characterized by high
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 7, Iss 1, p 161 (2012)
Diagnostic Pathology, Vol 7, Iss 1, p 161 (2012)
Background On the past decade a plethora of investigations were directed on identification of molecules involved in breast tumorogenesis, which could represent a powerful tool for monitoring, diagnostics and treatment of this disease. In current stud