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Publikováno v:
Diagnostic Pathology
Background The rate of progression of the disease depends on various factors and the tumor microenvironment takes not the last place among them. One part of researchers argues that the presence of tumor-infiltrating leukocytes serves as a favorable m
Publikováno v:
Diagnostic Pathology
Background: The histopathological subtype, nuclear grade and presence or absence of comedonecrosis are established as critical elements in the reporting of ductal carcinoma in situ (DCIS) of the breast. The aims of this study were to determine the fr
Publikováno v:
Diagnostic Pathology
Background The different expression level of Dickkopf-1 (DKK-1) in different cancers shows that the function of DKK-1 depends on the histological type of the cancer cells and the tissue microenvironment. To our knowledge, the serum expression level o
Publikováno v:
Diagnostic Pathology
Background Coactivator-associated arginine methyltransferase 1 (CARM1) belongs to the protein arginine methyltransferase family. CARM1 has been reported to be associated with high grade tumors in breast cancer. It still remains unknown the expression
Autor:
Kuniko Mibuchi, Hidejiro Higuchi, Shin-ichi Tsuchiya, Koichi Higaki, Toshiro Yokoyama, Mariko Nagao, Jiro Watanabe, Rin Yamaguchi, Takashi Koshikawa, Sonoe Ito, Masayoshi Kage, Yasuhide Nonaka, Hirohisa Yano
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 7, Iss 1, p 53 (2012)
Diagnostic Pathology, Vol 7, Iss 1, p 53 (2012)
Background We previously investigated the current status of breast cytology cancer screening at seven institutes in our area of southern Fukuoka Prefecture, and found some differences in diagnostic accuracy among the institutions. In the present stud
Publikováno v:
Diagnostic Pathology
Background NAD(P)H: quinone oxidoreductase 1 (NQO1) plays a central role in catalyzing the two-electron reduction of quinoid compounds into hydroquinones. The NQO1 Pro187Ser polymorphism was found to correlate with a lower enzymatic activity, which m
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 6, Iss 1, p 74 (2011)
Diagnostic Pathology, Vol 6, Iss 1, p 74 (2011)
Background Using new molecular biology techniques, recent studies have implicated a common evolutionary pathway between lobular neoplasia, lobular carcinomas, and columnar cell lesions. Our aims were to assess the frequency of lobular neoplasia in a
Autor:
Ghadeer A Mokhtar, Samia Al Amoudi, Rana Y. Bokhary, Zuhoor K Al-Gaithy, Najlaa Bin Mahfouz, Eman Emam, Fadwa J. Altaf
Publikováno v:
Diagnostic Pathology
Background Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of metaplastic breast carcinoma and
Autor:
Claudio Eccher, Mattia Barbareschi, Silvia Fasanella, Luca Morelli, D. Aldovini, F. Gasperetti, Gabriella Berlanda, E. Leonardi, Emma Bragantini, I Bazzanella, Lucia Veronica Cuorvo, P. Dalla Palma, Antonella Ferro, Chiara Cantaloni
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 6, Iss Suppl 1, p S7 (2011)
Diagnostic Pathology, Vol 6, Iss Suppl 1, p S7 (2011)
Background Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation. Aim To test the
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 7, Iss 1, p 32 (2012)
Diagnostic Pathology, Vol 7, Iss 1, p 32 (2012)
Background Breast cancer is the most common cancer and the leading cause of cancer mortality in women worldwide. Hypoxia is an important factor involved in the progression of solid tumors and has been associated with various indicators of tumor metab