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Autor:
Ch. Kugler, N. Reinmuth, Torsten Goldmann, J. Müller, Rania Gaber, M. Reck, Arne Warth, Danny Jonigk, Iris Watermann, B. Schmitt, Peter Zabel, Ekkehard Vollmer, Rudolf M. Huber, Michael Thomas, Florian Stellmacher, K F Rabe
Publikováno v:
Diagnostic Pathology
Background Several c-MET targeting inhibitory molecules have already shown promising results in the treatment of patients with Non-small Cell Lung Cancer (NSCLC). Combination of EGFR- and c-MET-specific molecules may overcome EGFR tyrosine kinase inh
Autor:
Gonzalo de Toro, Milind Javle, Xabier de Aretxabala, Anakaren Game, Sergio Muñoz, Ivan Roa, Fernanda Fernández
Publikováno v:
Diagnostic Pathology
Background PTEN is a tumor suppressor gene that regulates the PTEN/PI3k/AKT/mTOR pathway, which is frequently altered in human cancers including gallbladder cancer (GBC). To determine the frequency of PTEN expression in GBC and to establish its relat
Autor:
Annamaria Anniciello, Gabriella Aquino, L. Panico, Fioravante Ronconi, Annarosaria De Chiara, Renato Franco, Luigi Russo
Publikováno v:
Diagnostic Pathology
Diagnostic Pathology, Vol 7, Iss 1, p 79 (2012)
Diagnostic Pathology, Vol 7, Iss 1, p 79 (2012)
Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a c
Publikováno v:
Diagnostic Pathology, Vol 5, Iss 1, p 35 (2010)
Diagnostic Pathology
Diagnostic Pathology
WOS: 000279955000001 PubMed: 20546613 Background: The aim of this study was to assess the relationship between expression of vascular endothelial growth factor (VEGF) and phosphatase and tensin homolog deleted in chromosome ten (PTEN), angiogenesis a
Publikováno v:
Diagnostic Pathology
Objective p21-activated kinase (PAK) 2, as a member of the PAK family kinases, is involved in a number of hallmark processes including cell proliferation, survival, mitosis, apoptosis, motility and angiogenesis. However, the clinical significance of