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Autor:
Hiroaki Masuzaki, Masayuki Matsushita, Masato Tsutsui, Keiko Abe, Tadashi Kaname, Chisayo Kozuka, Chitoshi Takayama, Chigusa Shimizu-Okabe
Publikováno v:
Diabetologia
Aims/hypothesis Overeating of dietary fats causes obesity in humans and rodents. Recent studies in humans and rodents have demonstrated that addiction to fats shares a common mechanism with addiction to alcohol, nicotine and narcotics in terms of a d
The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Autor:
Erik Renström, Nikolina Papac-Milicevic, Anna M. Blom, Gunilla T. Westermark, Ben C. King, Klaudia Kulak
Publikováno v:
Diabetologia
Aims/hypothesis Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigg