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The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Autor:
Erik Renström, Nikolina Papac-Milicevic, Anna M. Blom, Gunilla T. Westermark, Ben C. King, Klaudia Kulak
Publikováno v:
Diabetologia
Aims/hypothesis Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigg