Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Zhiguang Zhou"'
Publikováno v:
Diabetes. 70
Context: Latent autoimmune diabetes in youth (LADY) falls in a grey zone of the current diabetes scheme due to the lack of established definition and diagnosis criteria. Objective: To investigate the prevalence and clinical features of LADY patients
Publikováno v:
Diabetes. 70
Type 1 diabetes (T1D) is an immune-mediated disease characterized by impairment of pancreatic beta cells. To date, a comprehensive cure is not available. Th1 cell activation is considered a key mediator of the pathogenesis of T1D. IL-12-induced STAT4
Autor:
Wei Liu, Yalun Xiao, Ting Xiao, Guangdi Li, Fang Hu, Zhiguang Zhou, Hailan Liu, Linyun He, Feng Liu, Mowei Tang, Feng Zhang
Publikováno v:
Diabetes. 67:2585-2600
miRNAs are important regulators of differentiation, development, and function of brown and beige fat cells. In this study, we identify the role of the miR-199a/214 cluster in the regulation of brown and beige adipocyte development and thermogenesis i
Publikováno v:
Diabetes. 69
Background: Exposure of pancreatic β-cell to proinflammatory cytokines released by islet-infiltrating immune cells will lead to impaired insulin production and secretion as well as β-cell apoptosis during the initial phase of type 1 diabetes (T1D).
Autor:
Ran Yuan, Zhiguang Zhou, Liufeng Mao, Xiaofeng Tang, Lise Madsen, Pentao Liu, Baoming Nie, Peng Li, Yu Wang, Tao Nie, Sheng Ding, Donghai Wu, Xuefei Gao, Xiaoliang Lin, Ke Ding, Weiping Han, Kuai Li, Jian Fei, Karsten Kristiansen, Xiaoyan Hui, Yong Xu, Xin Liu, Aimin Xu
Publikováno v:
Diabetes. 66:407-417
Both mammals and adult humans possess classic brown adipocytes and beige adipocytes, and the amount and activity of these adipocytes are considered key factors in combating obesity and its associated metabolic diseases. Uncoupling protein 1 (Ucp1) is
Publikováno v:
Diabetes. 68
Objective: To describe a novel integrated outpatient diabetes management system set up in China. To evaluate its effectiveness in type 1 diabetes (T1D) control. Methods: A multiple disciplinary clinic, assembling a diabetologist, a diabetes education
Publikováno v:
Diabetes. 68
Programmed death-1 (PD-1) critically regulates T cell tolerance, but the role of PD-1/PD-L1 in the pathogenesis of type 1 diabetes (T1D) patients remains unclear. In this study, we investigated circulating PD-1+/PD-L1+ T cells and their changes durin
Autor:
LINONG JI, WEIHONG SONG, HUI FANG, WEI LI, JIANLIN GENG, YAN CHENG XU, YANGANG WANG, LIAN GUO, HANQING CAI, TAO YANG, HONG-MEI LI, GANGYI YANG, QIFU LI, KUANZHI LIU, SHUYING LI, YANJUN LIU, FUYAN SHI, XIN SHENG LI, XIN GAO, QIUHE JI, HAOMING TIAN, QING SU, ZHIGUANG ZHOU, WENBO WANG, ZUNHAI ZHOU, XUEJUN LI, ZHIQIANG NING, XIANPING LU, WEIPING JIA
Publikováno v:
Diabetes. 68
Chiglitazar showed favorable effect on glycemic control and lipid modulation with well tolerated safety profile in phase 2 trials. This trial aimed to further compare the efficacy and safety of chiglitazar with placebo in patients with type 2 diabete
Autor:
Shu Zhang, Qin Ning, Jia Song, Chunxia Zhao, Xiaoyu He, Decio L. Eizirik, Dao Wen Wang, Fei Xiong, Jianfeng Zhou, Zhishui Chen, Qilin Yu, Cong-Yi Wang, Jia Cheng, Ping Yang, Zhiguang Zhou, Meng Zhang, Shuang Hu
Publikováno v:
Diabetes. 65:3384-3395
Previous studies including ours demonstrated that methyl-CpG–binding domain 2 (MBD2) acts as a reader to decipher DNA methylome-encoded information. We thus in the current study used Mbd2−/− mice as a model to dissect the impact of high-fat die
Autor:
Zhibin Hu, Hongbing Shen, Jianping Weng, Zhiguang Zhou, Xinyu Xu, Yong Gu, Tao Yang, Liping Yu, Hao Dai, Heng Chen, Min Sun, Mei Zhang, Xuqin Zheng, Shuai Zheng, Yang Chen, Hsiang-Ting Hsu, Hongwen Zhou, Meng Zhu, Yun Shi, Yun Cai, Kuanfeng Xu
Publikováno v:
Diabetes. 67
Type 1 diabetes (T1D) is a highly heritable autoimmune disease. Although more than 50 non-HLA risk loci have been identified, the strongest associations were observed in HLA regions in Caucasian populations. The aim of this study is to identify T1D r