Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jerry L. Nadler"'
Autor:
Abhishek Kulkarni, Margaret A. Morris, Marcia McDuffie, Lindsey Glenn, Maureen Gannon, Christopher A. Reissaus, Kara S. Orr, Sarah A. Tersey, Marimar Hernandez-Perez, Jerry L. Nadler, Annie R. Piñeros, Raghavendra G. Mirmira
Publikováno v:
Diabetes. 69
The type 1 diabetes (T1D) pathogenesis has been viewed as being initiated and propagated by directed autoimmunity against islet β cells. In recent years, we and others have taken a new perspective placing the β cell itself as the initiating cell. 1
Autor:
Kara S. Orr, Abhishek Kulkarni, Margaret A. Morris, Jerry L. Nadler, Raghavendra G. Mirmira, Christopher A. Reissaus, Marcia McDuffie, Sarah A. Tersey, Lindsey Glenn, Marimar Hernandez-Perez, Annie R. Piñeros
Publikováno v:
Diabetes. 69
The pathogenesis of type 1 diabetes (T1D) involves the interaction of the immune system with β cells. 12/15-lipoxygenase (12/15-LOX), an enzyme involved in arachidonic acid metabolism, is highly expressed in both β cells and macrophages. Global del
Autor:
Ryan M. Anderson, Gaurav Chopra, Chanelle Benjamin, Jonathan Fine, Jerry L. Nadler, Raghavendra G. Mirmira, Abass M. Conteh, Sarah A. Tersey, David J. Maloney, Marimar Hernandez-Perez, Jennifer B. Nelson, Kara S. Benninger, Amelia K. Linnemann
Publikováno v:
Diabetes
Islet β-cell dysfunction and aggressive macrophage activity are early features in the pathogenesis of type 1 diabetes (T1D). 12/15-Lipoxygenase (12/15-LOX) is induced in β-cells and macrophages during T1D and produces proinflammatory lipids and lip
Autor:
Kara S. Orr, Maureen Gannon, Sarah A. Tersey, Jerry L. Nadler, Raghavendra G. Mirmira, Christopher A. Reissaus, Abhishek Kulkarni, Margaret A. Morris, Marcia McDuffie, Marimar Hernandez-Perez, Annie Rocio Pineros Alvarez, Lindsey Glenn
Publikováno v:
Diabetes. 68
The pathogenesis of type 1 diabetes (T1D) involves the interaction of the immune system with β cells. 12/15-lipoxygenase (12/15-LOX), an enzyme involved in arachidonic acid metabolism, is expressed in both β cells and macrophages. Global deletion o
Autor:
Talin Haritunians, Craig L. Hanis, Nancy J. Cox, Yii-Der Ida Chen, Amy L. Williams, Laura J. Rasmussen-Torvik, Stephen S. Rich, Xiuqing Guo, Carlos A. Aguilar-Salinas, Rohit Varma, Noël P. Burtt, Clicerio Gonzalez-Villalpando, Carl D. Langefeld, W. Craig Johnson, Simin Liu, Nan Wang, Jerome I. Rotter, Jerry L. Nadler, Fouad Kandeel, Leslie J. Raffel, Xiaoyi Gao, Michael Y. Tsai, Darko Stefanovski, Thomas A. Buchanan, Jie Yao, Julie T. Ziegler, Lorena Orozco, Adrienne H. Williams, James S. Pankow, Jennifer E. Below, Rebecca D. Jackson, James Gauderman, Richard N. Bergman, Christopher A. Haiman, Tasha E. Fingerlin, Jill M. Norris, Mark O. Goodarzi, Heather M. Highland, Donald W. Bowden, Leora Henkin, Adrienne W. MacKay, Nicholette D. Palmer, Alicia Huerta-Chagoya, Richard M. Watanabe, Lynne E. Wagenknecht, Beverly M. Snively, Kent D. Taylor, Anny H. Xiang, Jinrui Cui
Publikováno v:
Diabetes
Diabetes, vol 64, iss 5
Palmer, ND; Goodarzi, MO; Langefeld, CD; Wang, N; Guo, X; Taylor, KD; et al.(2015). Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: The GUARDIAN (Genetics underlying diabetes in Hispanics) consortium. Diabetes, 64(5), 1853-1866. doi: 10.2337/db14-0732. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9hv950qn
Diabetes, vol 64, iss 5
Palmer, ND; Goodarzi, MO; Langefeld, CD; Wang, N; Guo, X; Taylor, KD; et al.(2015). Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: The GUARDIAN (Genetics underlying diabetes in Hispanics) consortium. Diabetes, 64(5), 1853-1866. doi: 10.2337/db14-0732. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9hv950qn
© 2015 by the American Diabetes Association. Insulin sensitivity, insulin secretion, insulin clearance, and glucose effectiveness exhibit strong genetic components, although few studies have examined their genetic architecture or influence on type 2
Autor:
Jerry L. Nadler, Sabai Myo Aye, Margaret A Hatcher, Kaiwen Ma, Mark H. Kaplan, Mathew J. Butcher, Elena V. Galkina, Anca D. Dobrian, Bronson A. Haynes, Qian Ma
Publikováno v:
Diabetes
Signal transducer and activator of transcription (STAT) 4 is one of the seven members of the STAT family. STAT4 has a prominent role in mediating interleukin-12–induced T-helper cell type 1 lineage differentiation. T cells are key players in the ma
Autor:
Viktor R. Drel, Irina G. Obrosova, Valeriy V. Lyzogubov, Nazar Mashtalir, Jerry L. Nadler, Olga Ilnytska, Ivan A. Pavlov
Publikováno v:
Diabetes. 56:2598-2608
OBJECTIVE—Subjects with dietary obesity and pre-diabetes have an increased risk for developing both nerve conduction slowing and small sensory fiber neuropathy. Animal models of this type of neuropathy have not been described. This study evaluated
Autor:
Gilbert Lavielle, Jerry L. Nadler, Karlene Maitland, Bingbing Jiang, Tony Verbeuren, Richard A. Cohen, Shanqin Xu, Jia-Li Gu, Hossein Bayat, Stefano Corda, Adriana Zuccollo
Publikováno v:
Diabetes. 55:110-119
Arachidonic acid metabolites, some of which may activate thromboxane A 2 receptors (TPr) and contribute to the development of diabetes complications, including nephropathy, are elevated in diabetes. This study determined the effect of blocking TPr wi
Publikováno v:
Diabetes. 43:1103-1107
The rate of atherosclerosis is accelerated in humans with diabetes. The adhesion of monocytes to the vascular endothelium is a key event in the development of atherosclerosis. Alloxan (ALX)-induced diabetes in rabbits causes leukocyte accumulation on
Autor:
Kaiwen Ma, Nelly A. Maybee, Margaret A. Morris, Elizabeth Kropf, James C. Garmey, Craig S. Nunemaker, Sarah A. Tersey, Jerry L. Nadler, Brian K. Stevens, Claudia Rival, Marcia McDuffie, Jeffrey D. Carter, Susanna R. Keller
Publikováno v:
Diabetes. 57(1)
OBJECTIVE— 12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic β-cells. It enhances interleuk