Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christie M. Ballantyne"'
Autor:
MARY R. ROONEY, JINGSHA CHEN, OLIVE TANG, CHRISTIE M. BALLANTYNE, ERIC BOERWINKLE, JUSTIN ECHOUFFO TCHEUGUI, CHIADI E. NDUMELE, RYAN DEMMER, JAMES S. PANKOW, PAMELA LUTSEY, LYNNE E. WAGENKNECHT, MORGAN GRAMS, ELIZABETH SELVIN, JOSEF CORESH
Publikováno v:
Diabetes. 71
Introduction: Proteomics could improve our understanding of the etiology of diabetes. We sought to identify proteomic signatures associated with incident diabetes. Method: We used data from the Atherosclerosis Risk in Communities (ARIC) Study (visit
1192-P: Diabetes-Related Proteomic Alterations: The Atherosclerosis Risk in Communities (ARIC) Study
Autor:
JUSTIN B. ECHOUFFO TCHEUGUI, JINGSHA CHEN, MARY R. ROONEY, OLIVE TANG, CHRISTIE M. BALLANTYNE, ERIC BOERWINKLE, CHIADI E. NDUMELE, JAMES S. PANKOW, RYAN DEMMER, PAMELA LUTSEY, MORGAN GRAMS, ELIZABETH SELVIN, JOSEF CORESH
Publikováno v:
Diabetes. 71
Introduction: There is a paucity of large-scale data from multiethnic populations on proteomic alterations related to type 2 diabetes, which could help identify prognostic mediators. Method: We analyzed 4,955 plasma proteins using SomaLogic v4.0 on 1
Autor:
Jerry L. Perrard, Antu Kalathookunnel Antony, Huaizhu Wu, Christie M. Ballantyne, Zeqin Lian, Hua Liu, Lothar Hennighausen, Pradip K. Saha, Xiaoyuan Dai Perrard, Sean M. Hartig, Aaron R. Cox
Publikováno v:
Diabetes. 70:720-732
CD11c+ macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC pol
Autor:
Steven B. Ketchum, Craig Granowitz, Rebecca A. Juliano, Philippe Gabriel Steg, Lixia Jiao, Christie M. Ballantyne, Ralph T. Doyle, Deepak L. Bhatt, Eliot A. Brinton, Jean-Claude Tardif
Publikováno v:
Diabetes. 70
Background: REDUCE-IT, a multinational, double-blind trial, randomized 8179 statin-treated patients with controlled low density lipoprotein cholesterol, elevated triglycerides, and cardiovascular (CV) risk, to icosapent ethyl (IPE) 4 grams daily or p
Publikováno v:
Diabetes. 70
Jak/STAT pathway plays key roles in inflammation and is highly activated in adipose tissue (AT) in obesity. Recently, inhibition of the Jak/STAT pathway with baricitinib, a Jak1/Jak2 inhibitor, has been demonstrated to accelerate clinical improvement
Autor:
Antu, Antony, Zeqin, Lian, Xiaoyuan Dai, Perrard, Jerry, Perrard, Hua, Liu, Aaron R, Cox, Pradip, Saha, Lothar, Hennighausen, Sean M, Hartig, Christie M, Ballantyne, Huaizhu, Wu
Publikováno v:
Diabetes
CD11c(+) macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC p
Autor:
Christie M. Ballantyne, Shushama Alam, Yuyin Liu, Mikhail Kosiborod, Mary Jane Elliott, Deepak L. Bhatt, Robert S. Rosenson, James A. de Lemos, Katherine E Mues, Christopher P. Cannon, Kiran Philip
Publikováno v:
Diabetes. 69
Background: Among people with ASCVD, those with T2D have excess CVD risk and derive greater absolute benefit from CVD risk reduction therapies. We describe the use of evidence-based therapies for secondary prevention in participants (pts) with T2D. M
Autor:
Anne C. Goldberg, Rebecca A. Juliano, Craig Granowitz, Jean-Claude Tardif, Steven B. Ketchum, Christie M. Ballantyne, Eliot A. Brinton, Michael I. Miller, Lixia Jiao, Terry A. Jacobson, Om P. Ganda, David M. Herrington, Francine K. Welty, Philippe Gabriel Steg, Deepak L. Bhatt, Robert S. Busch, Matthew J. Budoff, Ralph T. Doyle
Publikováno v:
Diabetes. 69
Background: Statin-treated patients with diabetes mellitus (DM) are at high cardiovascular (CV) risk. Methods: In REDUCE-IT, icosapent ethyl (IPE; 4 g/day) reduced CV risk vs. placebo in statin-treated patients with either DM plus risk factors or est
Publikováno v:
Diabetes. 69
Background: Aging (middle age) is usually associated with obesity and progressive low-grade inflammation in adipose tissue. However, how immune components in adipose tissue respond to aging is still not fully uncovered. Here, we sought to examine imm
Autor:
Dan Wang, Chiadi E Ndumele, Elizabeth Selvin, Olive Tang, Vijay Nambi, Christie M. Ballantyne, Yvonne Commodore-Mensah, Mariana Lazo, Justin B. Echouffo Tcheugui
Publikováno v:
Diabetes. 68
Background: It is unclear whether the “metabolically healthy” obese phenotype has low cardiovascular disease (CVD) risk. High-sensitivity cardiac troponin T (hs-cTnT), a biomarker of myocardial damage, characterizes subclinical CVD risk. We categ