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Autor:
Evgeniy Panzhinskiy, Haoning Cen, Timothy J. Kieffer, Mark O. Huising, Søs Skovsø, James D. Johnson, Xiaoke Hu, Honey Modi, Derek A. Dionne, Yiwei Bernie Zhao, Shouhong Xuan, Nicole A.J. Krentz, Nilou Noursadeghi, Cara E. Ellis, Francis C. Lynn, Yi Han Xia, Chieh Min Jamie Chu
Publikováno v:
Diabetes. 71:2612-2631
Heterogeneity within specific cell types is common and increasingly apparent with the advent of single cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β cells of the endocrine pan
Autor:
Madhu Khullar, Arasambattu Kannan Munirajan, Sathyamangala V Naga Prasad, Sudesh Ravi, Nitish R. Mahapatra, Durairajpandian Vishnuprabu, Ajit S. Mullasari, Bhavani S. Sahu, Marimuthu S Ravi, Sanjib Senapati, Viswanathan Mohan, Richa Garg, Jiaur R. Gayen, Venkatesan Radha, Venkat R. Chirasani, Saurabh Sharma, Dhanya R Iyer, Malapaka Kiranmayi, Lakshmi Subramanian, Prasanna K.R. Allu, Sakthisree Maghajoti, Sromona D Mukherjee
Publikováno v:
Diabetes. 71:538-553
Pancreastatin (PST), a chromogranin A (CHGA)-derived potent physiological dysglycemic peptide, regulates glucose/insulin homeostasis. We have identified a non-synonymous functional PST variant (p.Gly297Ser; rs9658664) that occurs in a large section o
Publikováno v:
Diabetes
Type 2 diabetes (T2D) is a growing cause of poor health, psychosocial burden, and economic costs worldwide. The pancreatic β-cell is a cornerstone of metabolic physiology. Insulin deficiency leads to hyperglycemia, which was fatal before the availab
Autor:
Kai Zhang, Xiu Chen, Jinyang Xie, Li Yuan, Xingjing Liu, Xiao Han, Yao Wang, Peng Sun, Qingzhao Yuan, Ting Xiao
Publikováno v:
Diabetes. 71:104-115
Calcium/calmodulin-dependent serine protein kinase (CASK) is involved in the secretion of insulin vesicles in pancreatic β-cells. The current study revealed a new in vivo role of CASK in glucose homeostasis during the progression of type 2 diabetes
Autor:
Khalil Bouyakdan, Cindy Baldwin, Scott A. Campbell, Maureen Gannon, Thierry Alquier, Vincent Poitout, Nathalie Jouvet, Jennifer L. Estall, Shannon E. Townsend
Publikováno v:
Diabetes
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects are pe
Autor:
Chang-Yun Cho, Isaac Park, Ji Seul Han, Jee Hyung Sohn, Yong Geun Jeon, Sangsoo Lim, Hyun-Woo Rhee, Sang Mun Han, Hahn Nahmgoong, Sun Kim, Yul Ji, Jae Bum Kim
Publikováno v:
Diabetes. 70:2756-2770
Reactive oxygen species (ROS) are associated with various roles of brown adipocytes. Glucose-6-phosphate dehydrogenase (G6PD) controls cellular redox potentials by producing NADPH. Although G6PD upregulates cellular ROS levels in white adipocytes, th
Autor:
Alexander Becker, Barbara Wardas, Maryam Amini, Veit Flockerzi, Andreas Beck, Stephan E. Philipp, Qiao Sen, Anouar Belkacemi, Claudia Fecher-Trost, Damian Martus, Houssein Salah
Publikováno v:
Diabetes. 70:2532-2544
Voltage-gated Ca2+ (Cav) channels consist of a pore-forming Cavα1 subunit and auxiliary Cavα2-δ and Cavβ subunits. In fibroblasts, Cavβ3, independent of its role as a Cav subunit, reduces the sensitivity to low concentrations of inositol-1,4,5-t
Autor:
Anna Permyakova, Rachel Ben-Haroush Schyr, Joseph Tam, Ronit Grinbaum, Michael Bergel, Shahar Azar, Yhara Arad, Liron Hefetz, Botros Moalem, Hadar Israeli, Itia Magenheim, Aya Bardugo, Arnon Haran, Danny Ben-Zvi, Abbas Al-Kurd
Publikováno v:
Diabetes
Bariatric operations induce weight loss, which is associated with an improvement in hepatic steatosis and a reduction in hepatic glucose production. It is not clear whether these outcomes are entirely due to weight loss, or whether the new anatomy im
Autor:
Trevor J. Biden, Gemma L. Pearson, Scott A. Soleimanpour, Morgan A. Gingerich, Emily M. Walker
Publikováno v:
Diabetes
Insulin-producing pancreatic β-cells are central to glucose homeostasis, and their failure is a principal driver of diabetes development. To preserve optimal health β-cells must withstand both intrinsic and extrinsic stressors, ranging from inflamm
Autor:
Alfred K. Ramirez, Weikang Cai, Jong Hun Kim, C. Ronald Kahn, Brian T. O’Neill, Ruben Garcia-Martin, Xuemei Zhang, Thiago M. Batista, Samir Softic, Jason K. Kim, Masahiro Konishi, Guoxiao Wang
Publikováno v:
Diabetes
The brain is now recognized as an insulin-sensitive tissue; however, the role of changing insulin concentrations in the peripheral circulation in gene expression in the brain is largely unknown. Here, we performed a hyperinsulinemic-euglycemic clamp