Zobrazeno 1 - 10
of 877
pro vyhledávání: '"Diabetes Mellitus"'
Autor:
Martin Hrabé de Angelis, Rainer Lehmann, Norbert Stefan, Jürgen Machann, Hans Hauner, Stefan Kabisch, Peter Schwarz, Michael Roden, Fritz Schick, Stefan R. Bornstein, Kostantinos Kantartzis, Andreas L. Birkenfeld, Louise Fritsche, Andreas Peter, Andreas Fritsche, Corinna Dannecker, Stefan Kopf, Julia Clavel, Annette Schürmann, Martin Heni, Robert Wagner, Andreas Pfeiffer, Matthias Blüher, Vera Valenta, Katharina S. Weber, Andreas Lechner, Peter P. Nawroth, Hans-Ulrich Häring, Jochen Seißler, Renate Schick, Michael Stumvoll, Ulrike Dambeck, Michael Laxy, Karsten Müssig
Publikováno v:
Diabetes. 70:2785-2795
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes with low risk (LR) benefit from conventional LI and individuals with high risk (HR) ben
Autor:
Fiona M. Gribble, Robert Hansford, Maik Pietzner, Nicholas Bowker, A. Mesut Erzurumluoglu, Christopher N. Foley, Nicholas J. Wareham, Pallav Bhatnagar, Frank Reimann, Isobel D. Stewart, Eleanor Wheeler, Victoria P W Auyeung, Claudia Langenberg, Stephen Burgess, Matthew P. Coghlan
Publikováno v:
Diabetes
There is considerable interest in GIPR agonism to enhance the insulinotropic and extrapancreatic effects of GIP, thereby improving glycemic and weight control in type 2 diabetes (T2D) and obesity. Recent genetic epidemiological evidence has implicate
Autor:
Josephine H. Li, Jose C. Florez, Ewan R. Pearson, Adem Y. Dawed, Lukasz Szczerbinski, Varinderpal Kaur, Jennifer N. Todd
Publikováno v:
Diabetes
There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to antidiabetic medications. Polygenic scores provide increasing power to detect patterns of disease predisposition
Autor:
Paul K. Mazaika, Michael Tansey, Hanyang Shen, Kimberly Englert, Lara C. Foland-Ross, Stuart A. Weinzimer, Allan L. Reiss, Gabby Tong, Nelly Mauras, Neil H. White, Tandy Aye, Allison Cato
Publikováno v:
Diabetes
Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (mean ± SD ag
Autor:
Frances M. Ashcroft, Russell Joynson, Thomas Hill, Raul Terrón-Expósito, Peter Proks, Gregor Sachse, Elizabeth Haythorne, Liz Bentley, Roger D. Cox, Stephen J. Tucker
Publikováno v:
Diabetes. 70:1145-1156
The ATP-sensitive K+ (KATP) channel controls blood glucose levels by coupling glucose metabolism to insulin secretion in pancreatic β-cells. E23K, a common polymorphism in the pore-forming KATP channel subunit (KCNJ11) gene, has been linked to incre
Publikováno v:
Diabetes. 70
Objective: The rapid emergence of the SARS-COV2 virus that caused COVID-19 pandemic in early 2020 led to authorities instituting lockdown protocols to curb spread of the virus. Prior studies in patients with T1DM have demonstrated a short-term favora
Autor:
Paula Wullenweber, William H. Landschulz, Qianyi Zhang, Christof M. Kazda, Juan P. Frias, Axel Haupt, Emmanuel Chigutsa, Jenny Y. Chien
Publikováno v:
Diabetes. 70
Basal insulin Fc (BIF; LY3209590) is a novel, once-weekly, long-acting IgG Fc-fusion protein assessed for the treatment of diabetes mellitus. A 32-week study evaluating the safety and efficacy of BIF vs. degludec in persons with T2DM previously treat
Autor:
Rima Rida, Alex J. Manzano
Publikováno v:
Diabetes. 70
With the increasing prevalence of type 2 diabetes mellitus (T2DM) around the world, along with a population that is living longer, there is a need to provide elderly patients with technological advances in the management of diabetes mellitus. The use
Autor:
Kristine Kuchta, Daniel Amusin, Michelle Campbell, Lynn Tucker, Liana K. Billings, Michael B. Ujiki, Tatum Ewing
Publikováno v:
Diabetes. 70
Background: GLP1RAs are an increasingly common treatment in the setting of type 2 diabetes mellitus (T2DM). One hypothesized mechanism by which bariatric surgery contributes to T2DM remission is by increasing intestinal GLP-1 secretion. We aimed to e
Autor:
Jerome I. Rotter, Jordi Merino
Publikováno v:
Diabetes
It is an unexpected but pleasant surprise when new clinical relationships are identified, and one of the most interesting is the inverse association between LDL cholesterol (LDLc) and type 2 diabetes (T2D) risk. Evidence from both randomized clinical