Zobrazeno 1 - 10
of 1 026
pro vyhledávání: '"Diabetes Mellitus"'
Autor:
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Publikováno v:
Diabetes. 71:1073-1080
The pdx1−/− zebrafish mutant was recently established as a novel animal model of diabetic retinopathy. In this study, we investigate whether knockout of pdx1 also leads to diabetic kidney disease (DKD). pdx1−/− larvae exhibit several signs of
Autor:
Kelly Rogers Keene, Farook Jahoor, Ruchi Gaba, Sanjeet Patel, Surya N. Mulukutla, Rasmus Bennet, Eunice I. Caducoy, Paras B. Mehta, Ashok Balasubramanyam, Åke Lernmark, W. Frank Peacock, Jean W. Hsu
Publikováno v:
Diabetes
When stable and near-normoglycemic, patients with “A−β+” ketosis-prone diabetes (KPD) manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop diabetic ketoacidosis (DKA). To understa
Publikováno v:
Diabetes
Two-thirds of people with type 2 diabetes mellitus (T2DM) have or will develop chronic kidney disease (CKD), which is characterized by rapid renal decline that, together with superimposed T2DM-related metabolic sequelae, synergistically promotes earl
Autor:
Josephine H. Li, Jose C. Florez, Ewan R. Pearson, Adem Y. Dawed, Lukasz Szczerbinski, Varinderpal Kaur, Jennifer N. Todd
Publikováno v:
Diabetes
There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to antidiabetic medications. Polygenic scores provide increasing power to detect patterns of disease predisposition
Autor:
Matthew L. Bettini, Maria Bettini
Publikováno v:
Diabetes
Critical insights into the etiology of type 1 diabetes (T1D) came from genome-wide association studies that unequivocally connected genetic susceptibility to immune cell function. At the top of the susceptibility are genes involved in regulatory T-ce
Autor:
Deirdre K. Luttrell, Miran A. Jaffa, Maria F. Lopes-Virella, Ionut Bebu, Timothy J. Lyons, Dcct, Kelly J. Hunt, Ayad A. Jaffa, John M. Lachin, Barbara H. Braffett, Louis M. Luttrell
Publikováno v:
Diabetes
We determined the relationship between plasma kallikrein and cardiovascular disease (CVD) outcomes as well as major adverse cardiovascular events (MACE) in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and
Autor:
Farooq Syed, Huanmei Wu, Olufunmilola Oyebamiji, Carmella Evans-Molina, Robert N. Bone, Preethi Krishnan, Sayali Talware, Sharmila Selvaraj
Publikováno v:
Diabetes
The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We used an informatics-based approach to develop a
Autor:
Amit Arora, Alexis C. Wood, Michelle Newell, Benjamin J. Renquist, Jose M. Ordovas, Jin Zhou, Yann C. Klimentidis
Publikováno v:
Diabetes
Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to
Autor:
Carla J. Greenbaum
Publikováno v:
Diabetes
The 2019 report of a randomized, placebo-controlled clinical trial demonstrating that immune therapy can delay the onset of clinical type 1 diabetes (T1D) in antibody-positive relatives by a median of 2 years stands out as a landmark in the decades-l
Publikováno v:
Diabetes. 70:1575-1580
Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. It was recently claimed that metformin, a first-line drug used for the treatment of type 2 diabetes, inhibits liver mGPD 30-50%