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Autor:
Kelly Rogers Keene, Farook Jahoor, Ruchi Gaba, Sanjeet Patel, Surya N. Mulukutla, Rasmus Bennet, Eunice I. Caducoy, Paras B. Mehta, Ashok Balasubramanyam, Åke Lernmark, W. Frank Peacock, Jean W. Hsu
Publikováno v:
Diabetes
When stable and near-normoglycemic, patients with “A−β+” ketosis-prone diabetes (KPD) manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop diabetic ketoacidosis (DKA). To understa
Autor:
Wei-Yi Chen, Chen-Xi Yu, Xu Han, Yong-Mei Zhong, Jun Yu, Fei Yuan, Xiong-Li Yang, Ling-Jie Cui, Wen-Long Sheng, Shi-Jun Weng
Publikováno v:
Diabetes. 70:1157-1169
Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury resistant, are dysfunctional in certain ne
Autor:
Eliana Garcia-Vaz, Abrar Ahmad, Anna V. Zetterqvist, Maria F. Gomez, Lisa Berglund, Rory J. McCrimmon, Jennifer E. Gallagher, Faisel Khan, Anna-Maria Dutius Andersson, Alison D. McNeilly
Publikováno v:
Diabetes. 69:424-435
Central to the development of diabetic macro- and microvascular disease is endothelial dysfunction, which appears well before any clinical sign but, importantly, is potentially reversible. We previously demonstrated that hyperglycemia activates nucle
Autor:
W. David Strain, Francesco Casanova, Jessica Tyrrell, Faisel Khan, Samuel E. Jones, Angela C. Shore, Kim M. Gooding, Beaumont Rn, Hanieh Yaghootkar, Andrew T. Hattersley, Timothy M. Frayling, Kunihiko Aizawa, Andrew R. Wood
Publikováno v:
Diabetes. 69:1072-1082
Urinary albumin-to-creatinine ratio (ACR) is a marker of diabetic nephropathy and microvascular damage. Metabolic-related traits are observationally associated with ACR, but their causal role is uncertain. Here, we confirmed ACR as a marker of microv
Autor:
N. Podkuychenko, Marina Vladimirovna Shestakova, Asker Y. Khapchaev, Alexander V. Vorotnikov, Maxim Skulachev, Vladimir P. Shirinsky, Tatiana Vlasik, Vadim Z. Lankin, I. S. Stafeev, Mikhail V. Samsonov
Publikováno v:
Diabetes. 70
In diabetes-associated hyperlipidemia, free fatty acids (FFAs) are thought to induce insulin resistance and endothelial dysfunction leading to vascular injury and cardiovascular T2DM complications. However, evidence is scarce regarding the effects of
Autor:
Paul F. Williams, Andrew Leask, Danqing Min, Sarah N. Parry, Xiaoyu Wang, Jacintha S. Lourdesamy, Stephen M. Twigg
Publikováno v:
Diabetes. 70
Introduction: CCN2, formerly known as CTGF, is a pro-fibrotic protein that is implicated in several diabetes-related complications. The role of CCN2 in mediating NASH fibrosis in diabetes has not been fully elucidated. We hypothesize that targeting l
Autor:
Takashi Ushiki, Masayoshi Masuko, Atsuko Honda, Michihiro Igarashi, Tadahisa Mikami, Hajime Ishiguro, Kazunori Sango, Hiroshi Kitagawa, Hirohito Sone
Publikováno v:
Diabetes. 70
Background: The extracellular matrix is associated with diabetic complications; however, chondroitin sulfate (CS) role remains unclear. Herein, genetically engineered mice lacking the rate-limiting CS-synthesizing enzyme, CS N-acetylgalactosaminyltra
Autor:
Vala Hamidi, Paivi Burke, Leslie Carter, Daniel G. Ines, Jeremy Pettus, Erin R. Giovannetti, Schafer Boeder, Adrienne Armstrong
Publikováno v:
Diabetes. 70
Individuals with T1D have an ineffective glucagon response to low glucose levels which predisposes them to episodes of hypoglycemia. SGLT-2 inhibitors (SGLT2i) do not increase and may even reduce hypoglycemia in clinical trials, yet the mechanism is
Publikováno v:
Diabetes. 70
Sodium glucose cotransporter-2 (SGLT2) inhibitors promote urinary glucose excretion, consequently reducing blood glucose. Previously we showed that 6 weeks of Dapagliflozin (Dapa) treatment improved insulin sensitivity and prevented weight gain. In a
Autor:
Owen Chan, Daniel A. Appadurai
Publikováno v:
Diabetes. 70
Recurrent hypoglycemia (RH) results in elevated lactate levels in the ventromedial hypothalamus that impair the counter-regulatory responses to hypoglycemia. While the mechanisms that enhance lactate production are not clear, our previous data sugges