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Autor:
Akiko Ohashi, Satoko Kawarasaki, Yoshihito Fujita, Tsuyoshi Goto, Hiroyuki Hasegawa, Nobuya Inagaki, Yasuo Oguri, Hiroto Minamino, Futoshi Furuya, Teruo Kawada, Nozomi Isomura
Publikováno v:
Diabetes. 68
Brown adipose tissue (BAT) is a key organ that produces heat and increases energy expenditure; its regulatory factors could be clinically useful in the treatment of obesity and diabetes. Tetrahydrobiopterin (BH4) is an essential co-factor of tyrosine
Autor:
Busarin Arunsak, Chanisa Thonusin, Nipon Chattipakorn, Wasana Pratchayasakul, Patchareeya Amput, Siriporn C. Chattipakorn, Siripong Palee
Publikováno v:
Diabetes. 68
Obesity and dyslipidemia cause mitochondrial dysfunction of skeletal muscle. Low dose atorvastatin impairs mitochondrial function of white muscle fibers but does not damage that of red muscle fibers. However, the effects of PCSK9 inhibitors and high
Autor:
Herbert Tilg, Jochen Dobner, Bernhard Radlinger, Susanne Kaser, Sarah Boentges, Sabrina Folie, Karin Salzmann, Florian Hornsteiner, Claudia Ress, Timon-Erik Adolph
Publikováno v:
Diabetes. 68
Enhanced glucose transport capacity of the intestinal epithelium, specifically enterocytes, is known to significantly contribute to systemic glucocorticoid (GC) - induced hyperglycemia. This effect is mainly dependent on overexpression of sodium gluc
Autor:
Todd A. Lydic, Sandra S Hammer, Yan Levitsky, Denis A. Proshlyakov, David Pegouske, Julia V. Busik, Artem Muchnik
Publikováno v:
Diabetes. 68
Mitochondrial damage precedes histopathological abnormalities in diabetic retinopathy (DR). Retinal endothelial cells (REC) have the highest level of Acid Sphingomyelinase (ASM) expression in the retina and the increase in ASM activity and ceramide p
Publikováno v:
Diabetes. 68
Objective: Despite intensive insulin treatment in patients with type 1 diabetes (T1D), their glycemic levels often do not reach the recommended target goal. We performed a network meta-analysis to evaluate the efficacy and safety of additional therap
Publikováno v:
Diabetes. 68
Introduction: Mitochondria are organelles that routinely undergo fission and fusion in a process known as mitochondrial dynamics. Increased mitochondrial fission is implicated in the pathogenesis of obesity, type 2 diabetes, and metabolic disease. DR
Autor:
Theodore Rudic, Xiaowen Bai, Larisa Emelyanova, David C. Kress, Arshad Jahangir, Gracious R. Ross, Farhan Rizvi, Catherine Warner
Publikováno v:
Diabetes. 68
Mechanisms by which metformin (Mtf) protects human heart in type 2 diabetes remain debated. We hypothesize that Mtf has a biphasic effect on mitochondria: it causes activation of respiration at low doses via AMPK signaling and inhibition at high dose
Autor:
Roberta de Souza Santos, Morvarid Kabir, Malini S. Iyer, Deborah J. Clegg, Rebecca K. Paszkiewicz, Orison O. Woolcott, Aaron P. Frank, Richard N. Bergman
Publikováno v:
Diabetes. 68
We have previously demonstrated in dogs that following exposure to a high fat diet for 16 weeks, the brain and peripheral penetrating CB1R antagonist Rimonabant (RIM) promoted adipose tissue beiging and decreased adipocyte cell size. It is hoped that
Autor:
Andrew W. Norris, Yunxia O'Malley, Idil Apak-Evans, Aliye Uc, Pavana G. Rotti, John F. Engelhardt
Publikováno v:
Diabetes. 68
Cystic fibrosis (CF) is a multi-organ disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR protein is most highly expressed in pancreatic ductal epithelium, where loss of its function leads to ducta
Autor:
Soo Lim, David Z.I. Cherney
Publikováno v:
Diabetes. 68
Objective: Recent studies showed that sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce the risk of cardiovascular events and mortality in patients with type 2 diabetes (T2D). However, the mechanisms underlying this effect remain unclear. We c