Zobrazeno 1 - 10
of 2 736
pro vyhledávání: '"Diabetes Mellitus"'
Autor:
Madhu Khullar, Arasambattu Kannan Munirajan, Sathyamangala V Naga Prasad, Sudesh Ravi, Nitish R. Mahapatra, Durairajpandian Vishnuprabu, Ajit S. Mullasari, Bhavani S. Sahu, Marimuthu S Ravi, Sanjib Senapati, Viswanathan Mohan, Richa Garg, Jiaur R. Gayen, Venkatesan Radha, Venkat R. Chirasani, Saurabh Sharma, Dhanya R Iyer, Malapaka Kiranmayi, Lakshmi Subramanian, Prasanna K.R. Allu, Sakthisree Maghajoti, Sromona D Mukherjee
Publikováno v:
Diabetes. 71:538-553
Pancreastatin (PST), a chromogranin A (CHGA)-derived potent physiological dysglycemic peptide, regulates glucose/insulin homeostasis. We have identified a non-synonymous functional PST variant (p.Gly297Ser; rs9658664) that occurs in a large section o
Autor:
Young-Hoon Lee, Gi-Seok Park, Hyung-Bin Lim, Woo-Hyuk Lee, Jung Yeul Kim, Min Su Kim, Min-Woo Lee
Publikováno v:
Diabetes. 70:2663-2667
Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are both relatively common systemic diseases and cause damage to the retina, such as inner retina reduction and microvascular impairment. The purpose of this study was to identify peripapillary r
Autor:
Kelly Rogers Keene, Farook Jahoor, Ruchi Gaba, Sanjeet Patel, Surya N. Mulukutla, Rasmus Bennet, Eunice I. Caducoy, Paras B. Mehta, Ashok Balasubramanyam, Åke Lernmark, W. Frank Peacock, Jean W. Hsu
Publikováno v:
Diabetes
When stable and near-normoglycemic, patients with “A−β+” ketosis-prone diabetes (KPD) manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop diabetic ketoacidosis (DKA). To understa
Autor:
Roberta Cappellari, Antonio Rosato, Serena Tedesco, Marianna D’Anna, Angelo Avogaro, Gian Paolo Fadini, Gaia Zuccolotto, Francesco Ivan Amendolagine, Mattia Albiero, Ludovica Migliozzi
Publikováno v:
Diabetes. 70:1767-1779
The mechanisms by which sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiovascular outcomes in people with diabetes are incompletely understood. Recent studies show that SGLT2i may increase the levels of circulating cells with vascul
Autor:
Xin-Ping Zhao, Isabelle Chenier, Shuiling Zhao, Janos G. Filep, John S.D. Chan, Jean-Baptiste Lattouf, Shao-Ling Zhang, Kana N. Miyata, Chao-Sheng Lo, Julie R. Ingelfinger, Jean-François Cailhier, Jean Ethier, Anindya Ghosh
Publikováno v:
Diabetes. 70:1388-1403
We investigated the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) overexpression in renal proximal tubular cells (RPTCs) on blood glucose, kidney injury and sodium-glucose co-transporter 2 (Sglt2) expression in diabetic Akita Nrf2-/-/N
Autor:
Wei-Yi Chen, Chen-Xi Yu, Xu Han, Yong-Mei Zhong, Jun Yu, Fei Yuan, Xiong-Li Yang, Ling-Jie Cui, Wen-Long Sheng, Shi-Jun Weng
Publikováno v:
Diabetes. 70:1157-1169
Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and generally thought to be injury resistant, are dysfunctional in certain ne
Autor:
Desmond A. Schatz, Clive Wasserfall, James J. Ross, Todd M. Brusko, Rhonda Bacher, Mark A. Atkinson, Xiaoru Dong, Kieran M. Mcgrail, Amanda L. Posgai, Martha Campbell-Thompson, Andrew Muir, Michael J. Haller, Xia Li, Daniel J. Perry
Publikováno v:
Diabetes
Exocrine pancreas abnormalities are increasingly recognized as features of type 1 diabetes. We previously reported reduced serum trypsinogen levels and in a separate study, smaller pancreata at and prior to disease onset. We hypothesized that three p
Autor:
Bruce W. Patterson, Omar Saffaf, Larisa Belaygorod, Connor Engel, Chao Yang, Fong-Fu Hsu, Clay F. Semenkovich, Mohamed A. Zayed, Nikolai Harroun, Xiaohua Jin, Kshitij A. Desai
Publikováno v:
Diabetes
De novo phospholipogenesis, mediated by choline-ethanolamine phosphotransferase 1 (CEPT1), is essential for phospholipid activation of transcription factors such as peroxisome proliferator–activated receptor α (PPARα) in the liver. Fenofibrate, a
Autor:
Wolfgang H. Dillmann, Anzhi Dai, Jorge Suarez, Federico Cividini, Christopher Benner, Jorge A. Suarez, Darren E. Casteel, Tanja Diemer, Majid Ghassemian, Sven Heinz, Brian T. Scott
Publikováno v:
Diabetes
Diabetes, vol 70, iss 3
Diabetes, vol 70, iss 3
The contribution of altered mitochondrial Ca2+ handling to metabolic and functional defects in type 2 diabetic (T2D) mouse hearts is not well understood. In this study, we show that the T2D heart is metabolically inflexible and almost exclusively dep
Autor:
Katherine R. Tuttle, Radica Z. Alicic
Publikováno v:
Diabetes
Diabetes, the “other pandemic,” has progressively increased in magnitude despite advances in knowledge about diabetes prevention over the last two decades (1). Therefore, diabetes will remain a major public health problem for the foreseeable futu