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Autor:
Evgeniy Panzhinskiy, Haoning Cen, Timothy J. Kieffer, Mark O. Huising, Søs Skovsø, James D. Johnson, Xiaoke Hu, Honey Modi, Derek A. Dionne, Yiwei Bernie Zhao, Shouhong Xuan, Nicole A.J. Krentz, Nilou Noursadeghi, Cara E. Ellis, Francis C. Lynn, Yi Han Xia, Chieh Min Jamie Chu
Publikováno v:
Diabetes. 71:2612-2631
Heterogeneity within specific cell types is common and increasingly apparent with the advent of single cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β cells of the endocrine pan
Publikováno v:
Diabetes
Signal regulatory protein SIRPγ (CD172G) is expressed on the surface of lymphocytes where it acts by engaging its ligand, CD47. SIRPG, which encodes SIRPγ, contains a non-synonymous coding variant, rs6043409, which is significantly associated with
Autor:
Katherine E. Santostefano, Fiona M. Docherty, Shane P.M. Williams, JaeAnn M. Dwulet, Maria S. Hansen, Richard K.P. Benninger, Kent Riemondy, Holger A. Russ, Ali H. Shilleh, Roberto Castro-Gutierrez, Taylor M. Triolo, Mark A. Wallet, Lucas H. Armitage, Clayton E. Mathews
Publikováno v:
Diabetes
Stem cell–derived β-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. T
Autor:
Devika P. Bagchi, Ormond A. MacDougald
Publikováno v:
Diabetes
Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate determination and differentiation have been extensively studied. Indeed
Autor:
Trevor J. Biden, Gemma L. Pearson, Scott A. Soleimanpour, Morgan A. Gingerich, Emily M. Walker
Publikováno v:
Diabetes
Insulin-producing pancreatic β-cells are central to glucose homeostasis, and their failure is a principal driver of diabetes development. To preserve optimal health β-cells must withstand both intrinsic and extrinsic stressors, ranging from inflamm
Autor:
Hui Pan, Cristina Aguayo-Mazzucato, Cristian Abarca, Ayush Midha, Priscila Carapeto, Susan Bonner-Weir, Joshua Andle
Publikováno v:
Diabetes
The aging of pancreatic β-cells may undermine their ability to compensate for insulin resistance, leading to the development of type 2 diabetes (T2D). Aging β-cells acquire markers of cellular senescence and develop a senescence-associated secretor
Autor:
Jing Zhang, David Grimm, Talitha van der Meulen, Supraja Saravanakumar, Mark O. Huising, Marcus F. Flisher, Sharon Lee
Publikováno v:
Diabetes. 70:1070-1083
Proliferation of pancreatic β-cells has long been known to reach its peak in the neonatal stages and decline during adulthood. However, β-cell proliferation has been studied under the assumption that all β-cells constitute a single, homogenous pop
Publikováno v:
Diabetes
Enrichment of human islets with syntaxin 4 (STX4) improves functional β-cell mass through a nuclear factor-κB (NF-κB)–dependent mechanism. However, the detailed mechanisms underlying the protective effect of STX4 are unknown. For determination o
Autor:
Maureen Gannon, Alexis U. Oguh, Xiaogdong Zhu, Morgan A. Gingerich, Doris A. Stoffers, Scott A. Soleimanpour
Publikováno v:
Diabetes
Current evidence indicates that proliferating β-cells express lower levels of some functional cell identity genes, suggesting that proliferating cells are not optimally functional. Pdx1 is important for β-cell specification, function, and prolifera
Publikováno v:
Diabetes 70, 303-312 (2021)
Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We