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pro vyhledávání: ''
Autor:
Seyed Mojtaba Ghiasi, Sólrun Petersen, Kristian Klindt, Oana Cheta, Thomas Mandrup-Poulsen, Marcelo J. Perone, Michal Marzec, Peter Arvan, Anders Tengholm, Sophie Emilie Bresson, Caroline Hede Andersen, Clara Prats, Sebastian Barg, Mingyu Yang, Muhammad Saad Khilji, Leena Haataja, Muhmmad Omar-Hmeadi, Björn Tyrberg, Celina Pihl, Tina Dahlby
Publikováno v:
Diabetes
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Although endoplasmic reticulum (ER) chaperone binding to mutant proinsulin has been reported, the role of protein chaperones in the handling of wild-type proinsulin is underinvestigated. Here, we have explored the importance of glucose-regulated prot
Autor:
Colin A. Leech, George G. Holz, Oleg G. Chepurny, Debbie C Thurmond, Frank Schwede, Rajakrishnan Veluthakal
Publikováno v:
Diabetes. 67:1999-2011
Glucose metabolism stimulates cell division control protein 42 homolog (Cdc42)-p21-activated kinase (Pak1) activity and initiates filamentous actin (F-actin) cytoskeleton remodeling in pancreatic β-cells so that cytoplasmic secretory granules can tr
Autor:
Cole M. Haynes, Adolfo Garcia-Ocaña, Misung Kim, Dirk Homann, Bennett Davenport, Mark A. Herman, Liora S. Katz, Jerry E. Chipuk, Lucy Li, Anna M Schulz, Donald K. Scott, Lee B Honig, Anil Kumar
Publikováno v:
Diabetes
Patients with both major forms of diabetes would benefit from therapies that increase β-cell mass. Glucose, a natural mitogen, drives adaptive expansion of β-cell mass by promoting β-cell proliferation. We previously demonstrated that a carbohydra
Autor:
John E. Cupit, Raghavendra G. Mirmira, Abass M. Conteh, Amelia K. Linnemann, Michelle Marasco, Evan M. Appleman, Christopher A. Reissaus
Publikováno v:
Diabetes
Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antio
Publikováno v:
Diabetes
Glucagon-like peptide 1 receptor (GLP1R) agonists are widely used to treat diabetes. However, their function is dependent on adequate GLP1R expression, which is downregulated in diabetes. GLP1R is highly expressed on pancreatic β-cells, and activati
Autor:
Penny E. Lovat, Kirsty S. Cullen, Catherine Arden, James Shaw, Minna Honkanen-Scott, Francesco P Zummo
Publikováno v:
Diabetes. 66:1272-1285
Studies in animal models of type 2 diabetes have shown that glucagon-like peptide 1 (GLP-1) receptor agonists prevent β-cell loss. Whether GLP-1 mediates β-cell survival via the key lysosomal-mediated process of autophagy is unknown. In this study,
Autor:
Gordon Turner, Jennifer Vogel, Sharon X. Wang, Thomas M. Smith, Brian DeChristopher, Jianning Yin, Liansheng Su, Amy Chen, Richard Zessis, Sena Fowler, Aaron C. Wilson, Alina Berdichevsky, Chun-Hao Chiu, Deborah M. Rothman, Frédéric Zecri, Heming Xing, Xinming Cai
Publikováno v:
Diabetes. 69(5)
Type 2 diabetes (T2D) is caused by loss of pancreatic β-cell mass and failure of the remaining β-cells to deliver sufficient insulin to meet demand. β-Cell glucolipotoxicity (GLT), which refers to combined, deleterious effects of elevated glucose
Autor:
Yuxia Zhou, Ming Zhang, Wanjin Hong, Yanpan Zheng, Tuanlao Wang, Liang Cheng Li, Xi Qiu, Zhiyu Liu, Ruijuan Zhuang, Shengmei Zhang, Xiaoqing Liu, Huiying Liu
Publikováno v:
Diabetes. 69(1)
Insulin secretion is tightly regulated by membrane trafficking. RILP (Rab7 interacting lysosomal protein) regulates the endocytic trafficking, but its role in insulin secretion has not been investigated. In this study, we found that overexpression of
Autor:
Li Xie, Subhankar Dolai, Edwin R. Chapman, Youhou Kang, Huanli Xie, Dan Zhu, Tao Liang, Herbert Y. Gaisano, Tairan Qin
Publikováno v:
Diabetes
Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate glucose-stimulated insulin secretion (GSIS). However, Syt-7’s precise exocytotic actions in β-cel
Publikováno v:
Diabetes. 67(10)
Stress-related changes in β-cell mRNA levels result from a balance between gene transcription and mRNA decay. The regulation of RNA decay pathways has not been investigated in pancreatic β-cells. We found that no-go and nonsense-mediated RNA decay