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Autor:
Katherine R. Tuttle, Radica Z. Alicic
Publikováno v:
Diabetes
Diabetes, the “other pandemic,” has progressively increased in magnitude despite advances in knowledge about diabetes prevention over the last two decades (1). Therefore, diabetes will remain a major public health problem for the foreseeable futu
Autor:
Ivan A. Valdez, Amalia Gastaldelli, Devjit Tripathy, Carolina Solis-Herrera, Aurora Merovci, Xi Chen, Muhammad A. Abdul-Ghani, Ralph A. DeFronzo
Publikováno v:
Diabetes
The aim of the current study was to evaluate the effect of sustained physiologic increase of ∼50 mg/dL in plasma glucose concentration on insulin secretion in normal glucose-tolerant (NGT) subjects. Twelve NGT subjects without family history of typ
Autor:
Kathrine Rose, Filip K. Knop, Nina L. Hansen, Torben Hansen, Sofie Hædersdal, Tina Vilsbøll, Alexander S. Christensen, Jens J. Holst, Heidi Storgaard
Publikováno v:
Diabetes
Sulfonylureas (SUs) provide an efficacious first-line treatment in patients with hepatocyte nuclear factor 1α (HNF1A) diabetes, but SUs have limitations due to risk of hypoglycemia. Treatment based on the incretin hormones glucose-dependent insulino
Autor:
Maria A. Ramos-Roman, Beverley Adams-Huet, Brian M. Casey, Majid M. Syed-Abdul, Elizabeth J. Parks
Publikováno v:
Diabetes
Milk production may involve a transient development of insulin resistance in nonmammary tissues to support redistribution of maternal macronutrients to match the requirements of the lactating mammary gland. In the current study, adipose and liver met
Publikováno v:
Diabetes. 69:624-633
Approximately 10% of patients with type 2 diabetes suffer from latent autoimmune diabetes in adults (LADA). This study provides a systematic assessment of the pathology of the endocrine pancreas of patients with LADA and for comparison in a first rat
Autor:
Frédérique Frisch, André C. Carpentier, Mélissa Pelletier, Serge Phoenix, Stéfane Lebel, Denis P. Blondin, Christophe Noll, Eric Turcotte, Anne-Marie Carreau, Stephen C. Cunnane, André Tchernof, Mélanie Nadeau, Laurent Biertho, Brigitte Guérin
Publikováno v:
Diabetes. 69:567-577
Reduced storage of dietary fatty acids (DFAs) in abdominal adipose tissues with enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and prediabetes. We measured DFA metabolism and organ partitioning using positron emis
Autor:
Liping Yu, Michael P. Morran, Dorothy J. Becker, Howard W. Davidson, Shuai Huang, Andrew D Vonberg, Massimo Pietropaolo, Charles F. Verge, Roberto Gianani, Maria Acevedo-Calado, Susan L. Pietropaolo, Stephen S. Rich, Carla J. Greenbaum, Santiago Schnell, Aaron W. Michels
Publikováno v:
Diabetes
We identified autoantibodies (AAb) reacting with a variant IA-2 molecule (IA-2var) that has three amino acid substitutions (Cys27, Gly608, and Pro671) within the full-length molecule. We examined IA-2var AAb in first-degree relatives of type 1 diabet
Publikováno v:
Diabetes
Individuals with type 1 diabetes have an impaired glucagon counterregulatory response to hypoglycemia. Sodium—glucose cotransporter (SGLT) inhibitors increase glucagon concentrations. We evaluated whether SGLT inhibition restores the glucagon count
Autor:
Bart O. Roep
Publikováno v:
Diabetes
Insulin secretory granules of pancreatic β-cells are complex intracellular organelles comprising many proteins with different catalytic activities and messenger functions (1). These subcellular organelles have a distinctive morphology in electron mi
Autor:
Chee W. Chia, Jennifer F. O’Connell, Pavan Auluck, Luigi Ferrucci, Qinghua Chen, Stefano Marenco, Min Zhu, Josephine M. Egan, Nicholas S. Huang, Caio Henrique Mazucanti, Pingbo Zhang, Doyle Lu Lang, Qing-Rong Liu
Publikováno v:
Diabetes
Human insulin (INS) gene diverged from the ancestral genes of invertebrate and mammalian species millions of years ago. We previously found that mouse insulin gene (Ins2) isoforms are expressed in brain choroid plexus (ChP) epithelium cells where ins