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Autor:
Antoinette Moran, David R. Jacobs, Lyn M. Steffen, Brigitte I. Frohnert, Julia Steinberger, Alan R. Sinaiko
Publikováno v:
Diabetes
The objective of this study was to describe longitudinal relations of serum total free fatty acids (FFAs) to insulin resistance (IR) and cardiovascular (CV) risk factors from adolescence into adulthood. The cohort included participants in a longitudi
Autor:
Jari Ovaska, Marco Bucci, Lauri Nummenmaa, Minna Soinio, Pirjo Nuutila, Jarna C. Hannukainen, Henry K. Karlsson, Jetro J. Tuulari, Jussi Hirvonen, Nina Savisto, Mika Helmiö, Paulina Salminen
Publikováno v:
Diabetes
Scopus-Elsevier
Scopus-Elsevier
Obesity and insulin resistance are associated with altered brain glucose metabolism. Here, we studied brain glucose metabolism in 22 morbidly obese patients before and 6 months after bariatric surgery. Seven healthy subjects served as control subject
Autor:
Marc C. Huisman, Nikie J. Hoetjes, Adriaan A. Lammertsma, Michaela Diamant, Lothar A. Schwarte, Richard G. IJzerman, Larissa W. van Golen
Publikováno v:
Diabetes, 62(8), 2898-2904. American Diabetes Association Inc.
van Golen, L W, Huisman, M C, IJzerman, R G, Hoetjes, N J, Schwarte, L A, Lammertsma, A A & Diamant, M 2013, ' Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes ', Diabetes, vol. 62, no. 8, pp. 2898-2904 . https://doi.org/10.2337/db12-1159
van Golen, L W, Huisman, M C, IJzerman, R G, Hoetjes, N J, Schwarte, L A, Lammertsma, A A & Diamant, M 2013, ' Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes ', Diabetes, vol. 62, no. 8, pp. 2898-2904 . https://doi.org/10.2337/db12-1159/-DC1
Diabetes
van Golen, L W, Huisman, M C, IJzerman, R G, Hoetjes, N J, Schwarte, L A, Lammertsma, A A & Diamant, M 2013, ' Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes ', Diabetes, vol. 62, no. 8, pp. 2898-2904 . https://doi.org/10.2337/db12-1159
van Golen, L W, Huisman, M C, IJzerman, R G, Hoetjes, N J, Schwarte, L A, Lammertsma, A A & Diamant, M 2013, ' Cerebral Blood Flow and Glucose Metabolism Measured With Positron Emission Tomography Are Decreased in Human Type 1 Diabetes ', Diabetes, vol. 62, no. 8, pp. 2898-2904 . https://doi.org/10.2337/db12-1159/-DC1
Diabetes
Subclinical systemic microvascular dysfunction exists in asymptomatic patients with type 1 diabetes. We hypothesized that microangiopathy, resulting from long-standing systemic hyperglycemia and hyperinsulinemia, may be generalized to the brain, resu
Autor:
Malek Kamoun, Ali Naji, Cornelia Dalton-Bakes, Maral Palangian, Kumar Vivek, Zaw Min, Eline T. Luning Prak, Eileen Markmann, Michael R. Rickels, Chengyang Liu, Clyde F. Barker, Carissa Fuller, Scott A. Soleimanpour, Richard D. Shlansky-Goldberg, Allen J. Chiou
Publikováno v:
Diabetes
The Clinical Islet Transplantation 07 (CIT07) protocol uses antithymocyte globulin and etanercept induction, islet culture, heparinization, and intensive insulin therapy with the same low-dose tacrolimus and sirolimus maintenance immunosuppression as
Autor:
Adrian Vella, Luca P. Farrugia, Chiara Dalla Man, Francesca Piccinini, Alan R. Zinsmeister, Claudio Cobelli, Matheni Sathananthan, John M. Miles, Robert A. Rizza
Publikováno v:
Diabetes
Exendin-(9,39) is a competitive antagonist of glucagon-like peptide-1 (GLP-1) at its receptor. However, it is unclear if it has direct and unique effects of its own. We tested the hypothesis that exendin-(9,39) and GLP-1-(9,36)amide have direct effec
Autor:
Robert L. Hanson, Tingwei Guo, Sayuko Kobes, Leslie J. Baier, Jamie Fleming, William C. Knowler, Clifton Bogardus, Yunhua L. Muller
Publikováno v:
Diabetes
Parent-of-origin effects were observed in an Icelandic population for several genetic variants associated with type 2 diabetes, including those in KLF14 (rs4731702), MOB2 (rs2334499), and KCNQ1 (rs2237892, rs231362). We analyzed parent-of-origin effe
Autor:
J. Christopher Eagon, Faidon Magkos, David Bradley, Olga Ilkayeva, Christopher B. Newgard, Samuel Klein, Brian N. Finck, George G. Schweitzer
Publikováno v:
Diabetes
It has been hypothesized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss induced by Roux-en-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glucose homeostasis
Autor:
Monica Vedovato, Carlo Artusi, Lucia Puricelli, Renato Millioni, Paolo Tessari, Monica Vettore, Mario Plebani, Diego Cecchet
Publikováno v:
Diabetes
We tested the effects of insulin on production of nitrous oxide (NO)-related substances (nitrites and nitrates [NOx]) after 15N-arginine intravenous infusion and on asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) concentratio
Autor:
Peter Nowotny, Esther Phielix, Dorothea Krog, Christian Herder, Maren Carstensen, Peter Schadewaldt, Michael Roden, Nanette C. Schloot, Julia Szendroedi, Gerald I. Shulman, Toru Yoshimura, Bettina Nowotny, Lejla Zahiragic
Publikováno v:
Diabetes
Several mechanisms, such as innate immune responses via Toll-like receptor-4, accumulation of diacylglycerols (DAG)/ceramides, and activation of protein kinase C (PKC), are considered to underlie skeletal muscle insulin resistance. In this study, we
Autor:
Paola Maffi, Antonello Pileggi, Domenico Corradi, Sara Tezza, R. D. Molano, Francesca D'Addio, Francesca Gatti, Paolo Fiorina, Melissa Chin, Mohamed H. Sayegh, Carmen Fotino, Antonio Secchi, Fabio Grassi, Maria Elena Ferrero, Rita Gatti, Andrea Vergani, Camillo Ricordi, Michele Podetta, Roberto Bassi
Publikováno v:
Diabetes
The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2XRs) sense ATP released during cell damage-activation, thus regulating T-cell activation. We aim to define the role of P2XRs during islet allograft rejection and to establish a no