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Autor:
Ilse Weets, Peter In't Veld, Neelke De Munck, Miriam Pipeleers-Marichal, Kristien Van Belle, Zhidong Ling, Nicole Buelens, Frans Gorus, Patrick Haentjens, Daniel Pipeleers
Publikováno v:
Diabetes
OBJECTIVE This study assesses β-cell replication in human donor organs and examines possible influences of the preterminal clinical conditions. RESEARCH DESIGN AND METHODS β-Cell replication was quantified in a consecutive series of n = 363 human o
Publikováno v:
Diabetes
OBJECTIVE The incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) account for up to 60% of postprandial insulin release in healthy people. Previous studies showed a reduced incretin effect in patients with
Autor:
Chun-Chung Chow, Peter C.Y. Tong, Gary T.C. Ko, Alice P.S. Kong, Linda W.L. Yu, Wing-Yee So, Hai-Lu Zhao, Juliana C.N. Chan, Ronald C.W. Ma, Xilin Yang
Publikováno v:
Diabetes
OBJECTIVE Insulin has mitogenic effects, although hyperglycemia may be a risk factor for cancer in type 2 diabetes. It remains uncertain whether use of insulin increases cancer risk because of its effect on cell growth and proliferation or decreases
Autor:
Marek Straczkowski, Irina Kowalska, Agnieszka Adamska, Slawomir Wolczynski, Ida Kinalska, Agnieszka Nikolajuk, Monika Karczewska-Kupczewska, Maria Gorska, Elzbieta Otziomek
Publikováno v:
Diabetes
OBJECTIVE Insulin resistance might play a role in the pathogenesis of polycystic ovarian syndrome (PCOS). The family of glycoprotein 130 (gp130) cytokines could influence insulin action. One of these cytokines is interleukin (IL)-6, which exerts a sh
Autor:
Oliver Korn, Manfred Hallschmid, Kamila Jauch-Chara, Jan Born, Matthias Mölle, Bernd Schultes, Werner Kern, Björn Rasch
Publikováno v:
Diabetes
OBJECTIVE In the treatment of diabetic patients, the long-acting insulin analog insulin detemir is less prone to induce weight gain than other insulin formulations. Assuming that because of its pharmacologic properties, detemir displays stronger cent
Autor:
Leo J. Hofland, Cornelia M. van Duijn, Jacqueline C.M. Witteman, Joseph A M J L Janssen, Michael P. Brugts, Steven W. J. Lamberts
Publikováno v:
Diabetes
OBJECTIVE There is a complex relationship between IGF-I, IGF binding proteins, growth hormone, and insulin. The IGF-I kinase receptor activation assay (KIRA) is a novel method for measuring IGF-I bioactivity in human serum. We speculated that determi
Autor:
Barbara E.K. Klein, Ronald Klein
Publikováno v:
Diabetes
Diabetic retinopathy (DR) was the leading cause of severe visual impairment (VI) in subjects 25–64 years of age in the U.S. 30 to 40 years ago (1,2). At that time, severe VI (best corrected visual acuity of 20/200 or worse in the better eye) was 25
Autor:
Torben Hansen, Lise Højbjerre, Allan Vaag, Mette P. Sonne, Amra Ciric Alibegovic, Oluf Pedersen, Bente Stallknecht, Gerrit van Hall, Flemming Dela, Jens J. Holst
Publikováno v:
Diabetes
Alibegovic, A C, Sonne, M P, Højbjerre, L, Hansen, T, Pedersen, O, van Hall, G, Holst, J J, Stallknecht, B, Dela, F & Vaag, A 2010, ' The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest ', Diabetes, vol. 59, no. 4, pp. 836-43 . https://doi.org/10.2337/db09-0918
Alibegovic, A C, Sonne, M P, Højbjerre, L, Hansen, T, Pedersen, O, van Hall, G, Holst, J J, Stallknecht, B, Dela, F & Vaag, A 2010, ' The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest ', Diabetes, vol. 59, no. 4, pp. 836-43 . https://doi.org/10.2337/db09-0918
OBJECTIVE The aim of this study was to determine whether the type 2 diabetes–associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest
Autor:
David Meyre, Guillaume Paré
Publikováno v:
Diabetes
Cystic fibrosis (CF) is the most common inherited disorder of childhood and is caused by autosomal recessive mutations in the CF transmembrane conductance regulator ( CFTR ) gene (1). CF is most common among Caucasian individuals, with a prevalence o
Publikováno v:
Diabetes
OBJECTIVE Intestinal lipoprotein production has recently been shown to be increased in insulin resistance, but it is not known whether it is regulated by insulin in humans. Here, we investigated the effect of acute hyperinsulinemia on intestinal (and