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Autor:
Ilona Goljan, Seley Gharanei, Yonas Ghebremichael Weldeselassie, Christos Bagias, Bee K. Tan, Nithya Sukumar, Jens J. Holst, Ponnusamy Saravanan
Publikováno v:
Diabetes. 67:2650-2656
Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women (n = 14
Publikováno v:
Diabetes
Insulin clearance is a highly variable and important factor that affects circulating insulin concentrations. We developed a novel model-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and C-peptide profil
Autor:
Claudio Cobelli, Adrian Vella
Publikováno v:
Diabetes
The study of β-cell function in vivo has been hampered by the relative inaccessibility of the pancreas as well as the hybrid exocrine/endocrine nature of the organ. This has limited the ability to correlate structure with function, although some eff
Publikováno v:
Diabetes
The incretin effect, reflecting the enhancement of postprandial insulin secretion by factors including the intestinal hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, increases in proportion to meal size. How
Autor:
Wayne S. Cutfield, Jane E. Harding, Elizabeth Robinson, José G. B. Derraik, Janene B. Biggs, Paul L. Hofman, Stuart R Dalziel, Craig Jefferies, Sarah Mathai
Publikováno v:
Diabetes
We aimed to evaluate insulin secretion and insulin sensitivity in adults born preterm and their children. Subjects were adults born both preterm and at term, with their children aged 5–10 years born at term. Insulin sensitivity and secretion were a
Autor:
David E. Cummings, David A. D'Alessio, Jenny Tong, Harold W. Davis, Matthias H. Tschöp, Ronald L. Prigeon, Steven E. Kahn, Martin Bidlingmaier
Publikováno v:
Diabetes
OBJECTIVE The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. The goal of this study was to t
Autor:
Lucia Frittitta, Sabrina Prudente, Roberto Baratta, Dora Sudano, Fabio Pellegrini, Angela Nigro, Maria Grazia Farina, Vincenzo Trischitta, Fabrizio Barbetti, Paola Rossetti
Publikováno v:
Europe PubMed Central
Diabetes
Diabetes
OBJECTIVE— To study the role of the ENPP1 Q121 variant on glucose homeostasis in whites from Italy.RESEARCH DESIGN AND METHODS— We conducted case-control studies in 764 adults (from two independent samples of 289 nonobese and 485 obese individual
Autor:
Allan Vaag, Pernille Poulsen
Publikováno v:
Diabetes. 55:1819-1825
According to the “fetal origins hypothesis,” monozygotic (MZ) twins may be more prone to develop various metabolic abnormalities compared with dizygotic (DZ) twins, and twins all together may be more predisposed to metabolic defects compared with
Autor:
Tracey McLaughlin, Gerald M. Reaven, Kenneth S. Polonsky, Cindy Lamendola, Sun H. Kim, Fahim Abbasi, James W. Chu
Publikováno v:
Diabetes. 54:2447-2452
Compensatory hyperinsulinemia permitting insulin-resistant individuals to maintain normal glucose tolerance is associated with a left shift in the glucose-stimulated insulin secretion rate (GS-ISR) dose-response curve and decrease in the insulin meta
Publikováno v:
Diabetes. 53:2359-2365
Our objective was to study whether young first-degree relatives of patients with type 2 diabetes (FDRs) have altered insulin secretion and insulin clearance in response to gastric inhibitory polypeptide (GIP) in combination with glucose and arginine.