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Autor:
Archana Sharma, Sindre Lee-Ødegård, Elisabeth Qvigstad, Christine Sommer, Naveed Sattar, Jason M.R. Gill, Hanne L. Gulseth, Stina T. Sollid, Ingrid Nermoen, Kåre I. Birkeland
Publikováno v:
Diabetes
South Asian women have a higher risk of type 2 diabetes after gestational diabetes mellitus (GDM) than Nordic women; however, the mechanisms behind this difference remain unclear. We investigated insulin sensitivity, β-cell function, and hepatic ins
Autor:
Sarah C. Nyirjesy, Amy J. Peleckis, Jack N. Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J. Flatt, Diva D. De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A. D’Alessio, Ronald C. Rubenstein, Andrea Kelly, Michael R. Rickels
Publikováno v:
Diabetes. 71(10)
Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
Autor:
Swapan K Das, Dennis Montoya, Neeraj K. Sharma, Mary E. Comeau, Carl D. Langefeld, Matteo Pellegrini, Timothy D. Howard
Publikováno v:
Diabetes
Diabetes, vol 69, iss 12
Diabetes, vol 69, iss 12
Decline in insulin sensitivity due to dysfunction of adipose tissue (AT) is one of the earliest pathogenic events in type 2 diabetes. We hypothesize that differential DNA methylation (DNAm) controls insulin sensitivity and obesity by modulating trans
Autor:
Maria A. Ramos-Roman, Beverley Adams-Huet, Brian M. Casey, Majid M. Syed-Abdul, Elizabeth J. Parks
Publikováno v:
Diabetes
Milk production may involve a transient development of insulin resistance in nonmammary tissues to support redistribution of maternal macronutrients to match the requirements of the lactating mammary gland. In the current study, adipose and liver met
Autor:
Lærke S. Gasbjerg, Mette M. Rosenkilde, Amalie R. Lanng, Natasha C. Bergmann, Mikkel B. Christensen, Mads M. Helsted, Jens J. Holst, Maria Buur Nordskov Gabe, Tina Vilsbøll, Simon Veedfald, Bolette Hartmann, Alexander Hovard Sparre-Ulrich, Mette H. Jensen, Filip K. Knop, Signe Stensen
Publikováno v:
Diabetes. 68:906-917
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are secreted postprandially and contribute importantly to postprandial glucose tolerance. In this study, we assessed the individual and combi
Autor:
Mary Walter, Jonathan Krakoff, Karyne Lima Vinales, Clifton Bogardus, Brittany Begaye, Paolo Piaggi
Publikováno v:
Diabetes
Fibroblast growth factor 21 (FGF21) regulates energy expenditure (EE) and influences weight change during low-protein overfeeding in rodent models. The change in EE after a low-protein overfeeding diet is a predictor of weight change in humans and a
Autor:
Ilona Goljan, Seley Gharanei, Yonas Ghebremichael Weldeselassie, Christos Bagias, Bee K. Tan, Nithya Sukumar, Jens J. Holst, Ponnusamy Saravanan
Publikováno v:
Diabetes. 67:2650-2656
Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women (n = 14
Autor:
Devjit Tripathy, Juan Xiong, Felipe R. Lorenzo, Muhammad A. Abdul-Ghani, Donald A. McClain, Aurora Merovci, Ralph A. DeFronzo, Luke Norton, Chris E. Shannon
Publikováno v:
Diabetes
Chronic hyperglycemia causes insulin resistance, but the inheritability of glucotoxicity and the underlying mechanisms are unclear. We examined the effect of 3 days of hyperglycemia on glucose disposal, enzyme activities, insulin signaling, and prote
Autor:
Michelle, Carey, Eric, Lontchi-Yimagou, William, Mitchell, Sarah, Reda, Kehao, Zhang, Sylvia, Kehlenbrink, Sudha, Koppaka, Sylvan Roger, Maginley, Sandra, Aleksic, Shobhit, Bhansali, Derek M, Huffman, Meredith, Hawkins
Publikováno v:
Diabetes
Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this “glucose effectiveness” is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous syste
Autor:
Armand Mbanya, Ilan Gabriely, Meredith Hawkins, Nora Tomuta, Akankasha Goyal, Eric Lontchi-Yimagou, Harry Shamoon, Michelle Carey, Oana A. Sandu, Rebekah Gospin, Raphael Hulkower
Publikováno v:
Diabetes
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypo