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Autor:
Maria A. Ramos-Roman, Beverley Adams-Huet, Brian M. Casey, Majid M. Syed-Abdul, Elizabeth J. Parks
Publikováno v:
Diabetes
Milk production may involve a transient development of insulin resistance in nonmammary tissues to support redistribution of maternal macronutrients to match the requirements of the lactating mammary gland. In the current study, adipose and liver met
Autor:
Ilona Goljan, Seley Gharanei, Yonas Ghebremichael Weldeselassie, Christos Bagias, Bee K. Tan, Nithya Sukumar, Jens J. Holst, Ponnusamy Saravanan
Publikováno v:
Diabetes. 67:2650-2656
Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women (n = 14
Autor:
Armand Mbanya, Ilan Gabriely, Meredith Hawkins, Nora Tomuta, Akankasha Goyal, Eric Lontchi-Yimagou, Harry Shamoon, Michelle Carey, Oana A. Sandu, Rebekah Gospin, Raphael Hulkower
Publikováno v:
Diabetes
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypo
Publikováno v:
Diabetes. 66:2400-2406
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal (Rd). However, clamp conditions do not adequately mimic postprandial phy
Autor:
Ulla Kampmann, Janne R. Hingst, Niels Jessen, Jørgen F. P. Wojtaszewski, Mads Svart, Niels Møller, Thomas Schmidt Voss, Mikkel H. Vendelbo
Publikováno v:
Voss, T S, Vendelbo, M, Opstrup, U K, Hingst, J R, Wojtaszewski, J F P, Svart, M, Møller, N & Jessen, N 2017, ' Acute Hypoglycemia in Healthy Humans Impairs Insulin Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle; a Randomized Clinical Study ', Diabetes, vol. 66, no. 9, pp. 2483-2494 . https://doi.org/10.2337/db16-1559
Hypoglycemia is the leading limiting factor in glycemic management of insulin-treated diabetes. Skeletal muscle is the predominant site of insulin-mediated glucose disposal. Our study used a crossover design to test to what extent insulin-induced hyp
Autor:
Lykke Sylow, Christian Frøsig, Christopher S. Shaw, Erik A. Richter, Bente Kiens, Stephen Rattigan, Glenn K. McConell, Jørgen F. P. Wojtaszewski, Andrew C. Betik, Rasmus Kjøbsted, Kim A. Sjøberg, Maximilian Kleinert
Publikováno v:
Diabetes. 66:1501-1510
Insulin resistance is a major health risk, and although exercise clearly improves skeletal muscle insulin sensitivity, the mechanisms are unclear. Here we show that initiation of a euglycemic-hyperinsulinemic clamp 4 h after single-legged exercise in
Autor:
Li Xie, Subhankar Dolai, Edwin R. Chapman, Youhou Kang, Huanli Xie, Dan Zhu, Tao Liang, Herbert Y. Gaisano, Tairan Qin
Publikováno v:
Diabetes
Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate glucose-stimulated insulin secretion (GSIS). However, Syt-7’s precise exocytotic actions in β-cel
Publikováno v:
Diabetes
Insulin clearance is a highly variable and important factor that affects circulating insulin concentrations. We developed a novel model-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and C-peptide profil
Autor:
Joan Khoo, Michael Horowitz, Chinmay S. Marathe, Tongzhi Wu, Jessica Chang, Benjamin Crouch, Rachael S. Rigda, Christopher K. Rayner, Sony S. Thazhath, Michelle J. Bound, Karen L. Jones, Helen L. Checklin, Paul Kuo
Publikováno v:
Diabetes. 65:269-275
The short-acting glucagon-like peptide 1 receptor agonist exenatide reduces postprandial glycemia, partly by slowing gastric emptying, although its impact on small intestinal function is unknown. In this study, 10 healthy subjects and 10 patients wit
Autor:
Claudio Cobelli, Adrian Vella
Publikováno v:
Diabetes
The study of β-cell function in vivo has been hampered by the relative inaccessibility of the pancreas as well as the hybrid exocrine/endocrine nature of the organ. This has limited the ability to correlate structure with function, although some eff