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Publikováno v:
Diabetes. 53:2359-2365
Our objective was to study whether young first-degree relatives of patients with type 2 diabetes (FDRs) have altered insulin secretion and insulin clearance in response to gastric inhibitory polypeptide (GIP) in combination with glucose and arginine.
Autor:
Bente Klarlund Pedersen, Mark A. Febbraio, Massimo Sacchetti, Natalie Hiscock, Christian P. Fischer
Publikováno v:
Diabetes. 53:1643-1648
The mechanisms that mediate the tightly controlled production and clearance of glucose during muscular work are unclear, and it has been suggested that an unidentified “work factor” exists that influences the contraction-induced increase in endog
Autor:
Leszek Nosek, Eberhard Draeger, Lars Endahl, Birgitte Biilmann Rønn, Lutz Heinemann, Christoph Kapitza, Tim Heise
Publikováno v:
Diabetes. 53:1614-1620
The aim of this randomized double-blind study was to compare the within-subject variability of the glucose-lowering effect of a novel insulin analog, insulin detemir, with that of insulin glargine and NPH insulin in people with type 1 diabetes. Fifty
Autor:
Shoichiro Nagasaka, Shun Ishibashi, Tomoatsu Nakamura, Yuichiro Nishida, Ikuyo Kusaka, Kumpei Tokuyama, Yasuki Higaki, Munehiro Shindo, Hiroaki Tanaka, Akira Kiyonaga, Yoko Shirai
Publikováno v:
Diabetes. 53:315-320
For examining the effects of moderate exercise training on peripheral glucose effectiveness (S(g)(2)*), insulin sensitivity (S(i)(2)*), and endogenous glucose production (EGP), seven men and one woman (24.8 +/- 1.8 years) participated in cycle ergome
Autor:
Aron Adkins, W. Frederick Schwenk, Adrian Vella, Rita Basu, Mai Persson, Betty Dicke, Robert A. Rizza, Pankaj R Shah
Publikováno v:
Diabetes. 52:2213-2220
To determine the mechanism(s) by which insulin inhibits endogenous glucose production (EGP) in nondiabetic humans, insulin was infused at rates of 0.25, 0.375, or 0.5 mU. kg(-1). min(-1) and glucose was clamped at approximately 5.5 mmol/l. EGP, gluco
Autor:
W. Timothy Garvey, Soonho Kwon, Kimberly Pugh, Sara Shaughnessy, Richard L. Klein, Amy Hutto, Penny Wallace, Alicia J. Jenkins, Youlian Liao, Deyi Zheng
Publikováno v:
Diabetes. 52:453-462
The insulin resistance syndrome (IRS) is associated with dyslipidemia and increased cardiovascular disease risk. A novel method for detailed analyses of lipoprotein subclass sizes and particle concentrations that uses nuclear magnetic resonance (NMR)
Autor:
Mary C. Sugden, Mark J. Holness
Publikováno v:
Diabetes
Only 15–20% of obese individuals with severe insulin resistance develop type 2 diabetes mellitus (T2DM). In healthy individuals, β-cell compensation ensures that enhanced glucose-stimulated insulin secretion (GSIS) balances the degree of insulin r
Autor:
Leen M 't Hart, Giel Nijpels, Jacqueline M. Dekker, J. Antonie Maassen, Timon W. van Haeften, Robert J. Heine
Publikováno v:
Diabetes. 51:884-887
Associations between type 2 diabetes (and/or parameters contributing to glucose homeostasis) and genetic variation in the genes encoding insulin receptor substrate (IRS)-1 and -2 have been reported in several populations. Recently, it has been report
Autor:
Andrea Natali, Anna Maria Sironi, Ele Ferrannini, Amalia Gastaldelli, A Masoni, Andrea Mari, Elena Toschi, Stefania Camastra
Publikováno v:
Scopus-Elsevier
Diabetes (N.Y.N.Y.) 51 (2002).
info:cnr-pdr/source/autori:Toschi E., Camastra S., Sironi A.M., Masoni A., Gastaldelli A., Mari A., Ferrannini E., Natali A./titolo:Effect of acute hyperglycemia on insulin secretion in humans/doi:/rivista:Diabetes (N.Y.N.Y.)/anno:2002/pagina_da:/pagina_a:/intervallo_pagine:/volume:51
CIÊNCIAVITAE
Diabetes (N.Y.N.Y.) 51 (2002).
info:cnr-pdr/source/autori:Toschi E., Camastra S., Sironi A.M., Masoni A., Gastaldelli A., Mari A., Ferrannini E., Natali A./titolo:Effect of acute hyperglycemia on insulin secretion in humans/doi:/rivista:Diabetes (N.Y.N.Y.)/anno:2002/pagina_da:/pagina_a:/intervallo_pagine:/volume:51
CIÊNCIAVITAE
First-phase insulin response to intravenous glucose is impaired both in type 2 diabetic patients and in subjects at risk for the disease. Hyperglycemia can modify β-cell response by either inhibiting or potentiating both first- and second-phase insu
Autor:
C. Michael Johnson, Pankaj R Shah, Rita Basu, W. Frederick Schwenk, K. Sreekumaran Nair, Ananda Basu, Adrian Vella, Robert A. Rizza, Aron Adkins, Michael D. Jensen
Publikováno v:
Diabetes. 51:301-310
The present study sought to determine whether elevated plasma free fatty acids (FFAs) alter the ability of insulin and glucose to regulate splanchnic as well as muscle glucose metabolism. To do so, FFAs were increased in 10 subjects to approximately