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Autor:
Wayne S. Cutfield, Jane E. Harding, Elizabeth Robinson, José G. B. Derraik, Janene B. Biggs, Paul L. Hofman, Stuart R Dalziel, Craig Jefferies, Sarah Mathai
Publikováno v:
Diabetes
We aimed to evaluate insulin secretion and insulin sensitivity in adults born preterm and their children. Subjects were adults born both preterm and at term, with their children aged 5–10 years born at term. Insulin sensitivity and secretion were a
Autor:
Christian Meyer, Michael E. Lassman, Jon K. Moon, Stephen F. Previs, Anita Y H Lee, Ying Chen, Erica Wohlers-Kariesch, Kristin Butterfield, Shan Yang, Stephanie A. Parsons, Steven R. Smith, Manu Chakravarthy, Fanchao Yi, Christopher Bock, Jeffrey Spond
Publikováno v:
Diabetes. 66(1)
Glucagon (GCG) acutely stimulates energy expenditure (EE) and hepatic glucose production (HGP) in humans, but whether these effects persist during hyperglucagonemia of longer duration is unclear. Using a prospective, randomized, single-blind, crossov
Autor:
Astrid Hofer, Draženka Janković, Martin Krššák, Yvonne Winhofer, Christian-Heinz Anderwald, Anton Luger, Siegfried Trattnig, Michael Krebs, Gert Reiter
Publikováno v:
Diabetes
Increased myocardial lipid content (MYCL) recently has been linked to the development of cardiomyopathy in diabetes. In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resi
Autor:
Neda Rasouli, Philip A. Kern, Aiwei Yao-Borengasser, Neeraj Sharma, Steven C. Elbein, Swapan K Das
Publikováno v:
Diabetes
OBJECTIVE To determine altered gene expression profiles in subcutaneous adipose and skeletal muscle from nondiabetic, insulin-resistant individuals compared with insulin-sensitive individuals matched for BMI. RESEARCH DESIGN AND METHODS A total of 62
Autor:
Henriette Pilegaard, Louise D. Høeg, Bruno Bisiani, Kim A. Sjøberg, Jesper B. Birk, Christian Frøsig, Erik A. Richter, Bente Kiens, Jacob Jeppesen, Natalie Hiscock, Jørgen F. P. Wojtaszewski, Thomas E. Jensen
Publikováno v:
Diabetes
OBJECTIVE We have previously shown that overnight fasted women have higher insulin-stimulated whole body and leg glucose uptake despite a higher intramyocellular triacylglycerol concentration than men. Women also express higher muscle mRNA levels of
Autor:
David E. Cummings, David A. D'Alessio, Jenny Tong, Harold W. Davis, Matthias H. Tschöp, Ronald L. Prigeon, Steven E. Kahn, Martin Bidlingmaier
Publikováno v:
Diabetes
OBJECTIVE The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. The goal of this study was to t
Publikováno v:
Diabetes
OBJECTIVE The incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) account for up to 60% of postprandial insulin release in healthy people. Previous studies showed a reduced incretin effect in patients with
Autor:
Oliver Korn, Manfred Hallschmid, Kamila Jauch-Chara, Jan Born, Matthias Mölle, Bernd Schultes, Werner Kern, Björn Rasch
Publikováno v:
Diabetes
OBJECTIVE In the treatment of diabetic patients, the long-acting insulin analog insulin detemir is less prone to induce weight gain than other insulin formulations. Assuming that because of its pharmacologic properties, detemir displays stronger cent
Publikováno v:
Diabetes
OBJECTIVE Intestinal lipoprotein production has recently been shown to be increased in insulin resistance, but it is not known whether it is regulated by insulin in humans. Here, we investigated the effect of acute hyperinsulinemia on intestinal (and
Autor:
Jing Chen, Krzysztof C. Lewandowski, Bee K. Tan, Hendrik Lehnert, S Farhatullah, Jaspreet Kaur, Raghu Adya, D Heutling, Harpal S. Randeva, J. Paul O'Hare
Publikováno v:
Diabetes
OBJECTIVE To assess chemerin levels and regulation in sera and adipose tissue from women with polycystic ovary syndrome (PCOS) and matched control subjects. RESEARCH DESIGN AND METHODS Real-time RT-PCR and Western blotting were used to assess mRNA an