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Autor:
Ilona Goljan, Seley Gharanei, Yonas Ghebremichael Weldeselassie, Christos Bagias, Bee K. Tan, Nithya Sukumar, Jens J. Holst, Ponnusamy Saravanan
Publikováno v:
Diabetes. 67:2650-2656
Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women (n = 14
Publikováno v:
Diabetes
Insulin clearance is a highly variable and important factor that affects circulating insulin concentrations. We developed a novel model-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and C-peptide profil
Publikováno v:
Diabetes
The incretin effect, reflecting the enhancement of postprandial insulin secretion by factors including the intestinal hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, increases in proportion to meal size. How
Autor:
Wayne S. Cutfield, Jane E. Harding, Elizabeth Robinson, José G. B. Derraik, Janene B. Biggs, Paul L. Hofman, Stuart R Dalziel, Craig Jefferies, Sarah Mathai
Publikováno v:
Diabetes
We aimed to evaluate insulin secretion and insulin sensitivity in adults born preterm and their children. Subjects were adults born both preterm and at term, with their children aged 5–10 years born at term. Insulin sensitivity and secretion were a
Autor:
David E. Cummings, David A. D'Alessio, Jenny Tong, Harold W. Davis, Matthias H. Tschöp, Ronald L. Prigeon, Steven E. Kahn, Martin Bidlingmaier
Publikováno v:
Diabetes
OBJECTIVE The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. The goal of this study was to t
Autor:
Lucia Frittitta, Sabrina Prudente, Roberto Baratta, Dora Sudano, Fabio Pellegrini, Angela Nigro, Maria Grazia Farina, Vincenzo Trischitta, Fabrizio Barbetti, Paola Rossetti
Publikováno v:
Europe PubMed Central
Diabetes
Diabetes
OBJECTIVE— To study the role of the ENPP1 Q121 variant on glucose homeostasis in whites from Italy.RESEARCH DESIGN AND METHODS— We conducted case-control studies in 764 adults (from two independent samples of 289 nonobese and 485 obese individual
Publikováno v:
Diabetes. 53:2359-2365
Our objective was to study whether young first-degree relatives of patients with type 2 diabetes (FDRs) have altered insulin secretion and insulin clearance in response to gastric inhibitory polypeptide (GIP) in combination with glucose and arginine.
Publikováno v:
Diabetes. 48:2197-2203
With the release of the new 1997 American Diabetes Association diagnostic criteria, a new category was introduced, termed "impaired fasting glucose" (IFG). The metabolic abnormalities of individuals with IFG, compared with those with impaired glucose
Publikováno v:
Diabetes. 48:1572-1578
To elucidate potential mechanisms for insulin resistance occurring early in the development of type 2 diabetes, we studied 10 young healthy individuals, each with two first-degree relatives with type 2 diabetes, and 10 control subjects without known
Autor:
Laszlo Vadas, Fabrice Cerini, Alistair D. Kippen, Lan Vu, Keith Rose, Reto Stöcklin, Robin E. Offord
Publikováno v:
Diabetes. 46:44-50
Insulin levels in humans were measured by a new assay, the isotope dilution assay (IDA), based on stable isotope dilution mass spectrometry. A known amount of a deuterated analog of insulin was used as an internal standard and added to the serum samp