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Autor:
Armand Mbanya, Ilan Gabriely, Meredith Hawkins, Nora Tomuta, Akankasha Goyal, Eric Lontchi-Yimagou, Harry Shamoon, Michelle Carey, Oana A. Sandu, Rebekah Gospin, Raphael Hulkower
Publikováno v:
Diabetes
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypo
Publikováno v:
Diabetes. 66:2400-2406
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal (Rd). However, clamp conditions do not adequately mimic postprandial phy
Autor:
Ulla Kampmann, Janne R. Hingst, Niels Jessen, Jørgen F. P. Wojtaszewski, Mads Svart, Niels Møller, Thomas Schmidt Voss, Mikkel H. Vendelbo
Publikováno v:
Voss, T S, Vendelbo, M, Opstrup, U K, Hingst, J R, Wojtaszewski, J F P, Svart, M, Møller, N & Jessen, N 2017, ' Acute Hypoglycemia in Healthy Humans Impairs Insulin Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle; a Randomized Clinical Study ', Diabetes, vol. 66, no. 9, pp. 2483-2494 . https://doi.org/10.2337/db16-1559
Hypoglycemia is the leading limiting factor in glycemic management of insulin-treated diabetes. Skeletal muscle is the predominant site of insulin-mediated glucose disposal. Our study used a crossover design to test to what extent insulin-induced hyp
Autor:
Lykke Sylow, Christian Frøsig, Christopher S. Shaw, Erik A. Richter, Bente Kiens, Stephen Rattigan, Glenn K. McConell, Jørgen F. P. Wojtaszewski, Andrew C. Betik, Rasmus Kjøbsted, Kim A. Sjøberg, Maximilian Kleinert
Publikováno v:
Diabetes. 66:1501-1510
Insulin resistance is a major health risk, and although exercise clearly improves skeletal muscle insulin sensitivity, the mechanisms are unclear. Here we show that initiation of a euglycemic-hyperinsulinemic clamp 4 h after single-legged exercise in
Autor:
Li Xie, Subhankar Dolai, Edwin R. Chapman, Youhou Kang, Huanli Xie, Dan Zhu, Tao Liang, Herbert Y. Gaisano, Tairan Qin
Publikováno v:
Diabetes
Synaptotagmin (Syt)-7, a major component of the exocytotic machinery in neurons, is also the major Syt in rodent pancreatic β-cells shown to mediate glucose-stimulated insulin secretion (GSIS). However, Syt-7’s precise exocytotic actions in β-cel
Publikováno v:
Diabetes
Insulin clearance is a highly variable and important factor that affects circulating insulin concentrations. We developed a novel model-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and C-peptide profil
Autor:
Joan Khoo, Michael Horowitz, Chinmay S. Marathe, Tongzhi Wu, Jessica Chang, Benjamin Crouch, Rachael S. Rigda, Christopher K. Rayner, Sony S. Thazhath, Michelle J. Bound, Karen L. Jones, Helen L. Checklin, Paul Kuo
Publikováno v:
Diabetes. 65:269-275
The short-acting glucagon-like peptide 1 receptor agonist exenatide reduces postprandial glycemia, partly by slowing gastric emptying, although its impact on small intestinal function is unknown. In this study, 10 healthy subjects and 10 patients wit
Autor:
Claudio Cobelli, Adrian Vella
Publikováno v:
Diabetes
The study of β-cell function in vivo has been hampered by the relative inaccessibility of the pancreas as well as the hybrid exocrine/endocrine nature of the organ. This has limited the ability to correlate structure with function, although some eff
Publikováno v:
Diabetes. 64:3543-3553
Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secretion of insulin. Characterization of the in vitro dynamics of insulin secretion by perifused fragments of 10 human insulinomas permitted their subdivision into three fu
Autor:
Joachim Beige, Siegfried Eckert, Hermann Haller, Jelka Ahrens, Marcus May, Jens Jordan, Jan Menne, Stefan Engeli
Publikováno v:
Diabetes. 63:2833-2837
Arterial baroreflexes may regulate resistance vessels supplying glucose to skeletal muscle by modulating efferent sympathetic nervous system activity. We hypothesized that selective manipulation of baroreflex activity through electrical carotid sinus