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Autor:
Katherine R. Tuttle, Radica Z. Alicic
Publikováno v:
Diabetes
Diabetes, the “other pandemic,” has progressively increased in magnitude despite advances in knowledge about diabetes prevention over the last two decades (1). Therefore, diabetes will remain a major public health problem for the foreseeable futu
Publikováno v:
Diabetes. 69:624-633
Approximately 10% of patients with type 2 diabetes suffer from latent autoimmune diabetes in adults (LADA). This study provides a systematic assessment of the pathology of the endocrine pancreas of patients with LADA and for comparison in a first rat
Autor:
Frédérique Frisch, André C. Carpentier, Mélissa Pelletier, Serge Phoenix, Stéfane Lebel, Denis P. Blondin, Christophe Noll, Eric Turcotte, Anne-Marie Carreau, Stephen C. Cunnane, André Tchernof, Mélanie Nadeau, Laurent Biertho, Brigitte Guérin
Publikováno v:
Diabetes. 69:567-577
Reduced storage of dietary fatty acids (DFAs) in abdominal adipose tissues with enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and prediabetes. We measured DFA metabolism and organ partitioning using positron emis
Publikováno v:
Diabetes
Individuals with type 1 diabetes have an impaired glucagon counterregulatory response to hypoglycemia. Sodium—glucose cotransporter (SGLT) inhibitors increase glucagon concentrations. We evaluated whether SGLT inhibition restores the glucagon count
Autor:
Matthias B. Schulze, Clemens Wittenbecher, Annette Schürmann, Harald Grallert, Olga Kuxhaus, Andrea Teichmann, Karina Meidtner, Jennifer Kriebel, Heiner Boeing, Markus Jähnert, Meriem Ouni, Pascal Gottmann, Tobias Pischon
Publikováno v:
Diabetes 68, 188-197 (2019)
Recent studies suggest that insulin-like growth factor binding protein 2 (IGFBP-2) may protect against type 2 diabetes, but population-based human studies are scarce. We aimed to investigate the prospective association of circulating IGFBP-2 concentr
Autor:
Shelley S. Tworoger, Craig P. Hersh, Jae H. Kang, Tianyi Huang, Kimberly Glass, Frank B. Hu, Brenda M. Birmann, Kerry L. Ivey, Oana A. Zeleznik, Abhijeet R. Sonawane
Publikováno v:
Diabetes
Numerous studies have investigated individual biomarkers in relation to risk of type 2 diabetes. However, few have considered the interconnectivity of these biomarkers in the etiology of diabetes as well as the potential changes in the biomarker corr
Autor:
Ilona Goljan, Seley Gharanei, Yonas Ghebremichael Weldeselassie, Christos Bagias, Bee K. Tan, Nithya Sukumar, Jens J. Holst, Ponnusamy Saravanan
Publikováno v:
Diabetes. 67:2650-2656
Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women (n = 14
Autor:
Marie-France Hivert, Jose C. Florez, Michael Nodzenski, Catherine Allard, Luigi Bouchard, Denise M. Scholtens, Camille E. Powe, Catherine M. Briggs, Marysa V. Leya, Patrice Perron, William L. Lowe, Octavious Talbot
Publikováno v:
Diabetes
Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic trai
Autor:
Stephan van Vliet, Mihoko Yoshino, Han-Chow E. Koh, Samuel Klein, Bruce W. Patterson, Robert J. Gropler, Richard Laforest, Bettina Mittendorfer
Publikováno v:
Diabetes
We tested the hypothesis that obesity, independent of insulin resistance, is associated with increased insulin secretion. We compared insulin kinetics before and after glucose ingestion in lean healthy people and people with obesity who were matched
Publikováno v:
Diabetes. 69(12)
The heritability levels of two traits for diabetes diagnosis, serum fasting glucose (FG) and glycated hemoglobin (HbA1c), were estimated to be 51–62%. Studies have shown that cigarette smoking is a modifiable risk factor for diabetes. It is importa