Zobrazeno 71 - 80
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Autor:
Norbert Stefan, Andreas Peter, Jürgen Machann, Konstantinos Kantartzis, Silvia Wagner, Hans-Ulrich Häring, Alfred Königsrainer, Fritz Schick, Andreas Fritsche, Fausto Machicao, Ingmar Königsrainer
Publikováno v:
Diabetes
OBJECTIVE In a genome-wide association scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasti
Autor:
Emanuela V. Volpi, L Barak, Sian Ellard, Natalie Wilson, Laura J. McCulloch, Daniela Gasperikova, Iwar Klimes, Sara G.I. Suliman, N Misovicova, Emma L. Edghill, Juraj Stanik, Vilja Sandrikova, Anna L. Gloyn, Katherine S. Elliott
Publikováno v:
Diabetes
OBJECTIVE Digenic causes of human disease are rarely reported. Insulin via its receptor, which is encoded by INSR, plays a key role in both metabolic and growth signaling pathways. Heterozygous INSR mutations are the most common cause of monogenic in
Autor:
Baptist Gallwitz, Fausto Machicao, Günther Silbernagel, Karsten Müssig, Martina Guthoff, Harald Staiger, Jens J. Holst, Konstantinos Kantartzis, Hans-Ulrich Häring, Silke A. Schäfer, Andreas Fritsche, Kerstin Kirchhoff, Norbert Stefan
Publikováno v:
Diabetes
OBJECTIVE KCNQ1 gene polymorphisms are associated with type 2 diabetes. This linkage appears to be mediated by altered β-cell function. In an attempt to study underlying mechanisms, we examined the effect of four KCNQ1 single nucleotide polymorphism
Autor:
Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, Iozzo P, Nuutila P. Lindroos, M. M., Majamaa, Tura, Mari, Kalliokoski, K. K., Taittonen, M. T., Iozzo, Nuutila
Publikováno v:
Diabetes
Diabetes (N.Y.N.Y.) 58 (2009): 543–549. doi:10.2337/db08-0981
info:cnr-pdr/source/autori:Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, Iozzo P, Nuutila P. Lindroos, M. M., Majamaa, K., Tura, A., Mari, A., Kalliokoski, K. K., Taittonen, M. T., Iozzo, P. and Nuutila, P.,/titolo:m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction/doi:10.2337%2Fdb08-0981/rivista:Diabetes (N.Y.N.Y.)/anno:2009/pagina_da:543/pagina_a:549/intervallo_pagine:543–549/volume:58
Diabetes (N.Y.N.Y.) 58 (2009): 543–549. doi:10.2337/db08-0981
info:cnr-pdr/source/autori:Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, Iozzo P, Nuutila P. Lindroos, M. M., Majamaa, K., Tura, A., Mari, A., Kalliokoski, K. K., Taittonen, M. T., Iozzo, P. and Nuutila, P.,/titolo:m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction/doi:10.2337%2Fdb08-0981/rivista:Diabetes (N.Y.N.Y.)/anno:2009/pagina_da:543/pagina_a:549/intervallo_pagine:543–549/volume:58
OBJECTIVE—To study insulin sensitivity and perfusion in skeletal muscle together with the β-cell function in subjects with the m.3243A>G mutation in mitochondrial DNA, the most common cause of mitochondrial diabetes. RESEARCH DESIGN AND METHODS—
Autor:
Lucia Frittitta, Sabrina Prudente, Roberto Baratta, Dora Sudano, Fabio Pellegrini, Angela Nigro, Maria Grazia Farina, Vincenzo Trischitta, Fabrizio Barbetti, Paola Rossetti
Publikováno v:
Europe PubMed Central
Diabetes
Diabetes
OBJECTIVE— To study the role of the ENPP1 Q121 variant on glucose homeostasis in whites from Italy.RESEARCH DESIGN AND METHODS— We conducted case-control studies in 764 adults (from two independent samples of 289 nonobese and 485 obese individual
Autor:
James C. Engert, Alexandre Montpetit, Alexandre Belisle, Marie-Claude Vohl, Louis Pérusse, Ron Do, Claude Bouchard, Katia Desbiens, Swneke D. Bailey
Publikováno v:
Diabetes. 57:1147-1150
OBJECTIVE—A genome-wide association study conducted by the Wellcome Trust Case Control Consortium recently associated single nucleotide polymorphisms (SNPs) in the FTO (fatso/fat mass and obesity associated) gene with type 2 diabetes. These associa
Publikováno v:
Diabetes. 57:606-613
OBJECTIVE—Women with gestational diabetes mellitus (GDM) demonstrate chronic and progressive insulin resistance and a markedly increased risk of converting to type 2 diabetes after pregnancy. However, the cellular mechanisms underlying this insulin
Autor:
Patrizia Cioli, Geremia B. Bolli, Natalia Busciantella Ricci, Carmine G. Fanelli, Paolo Rossetti, Paola Candeloro, Francesca Porcellati
Publikováno v:
Diabetes. 57:746-756
OBJECTIVE—The acylated long-acting insulin analog detemir is more lipophilic than human insulin and likely crosses the blood-to-brain barrier more easily than does human insulin. The aim of these studies was to assess the brain/hypothalamus respons
Autor:
Yan Guo, Leslie J. Baier, Lijun Ma, Lorem N. Que, Clifton Bogardus, Robert L. Hanson, Sayuko Kobes
Publikováno v:
Diabetes
OBJECTIVE—A prior genome-wide association (GWA) study in Pima Indians identified variants within PCLO that were associated with early-onset type 2 diabetes. PCLO encodes a presynaptic cytomatrix protein that functions as a Ca2+ sensor that may be i
Autor:
Bjoern A. Menge, Juris J. Meier, Orlin Belyaev, Robert Drescher, Wolfgang Schmidt, Christophe A. Müller, Andrea Tannapfel, Waldemar Uhl
Publikováno v:
Diabetes. 57:142-149
OBJECTIVE—β-Cell regeneration has been proposed as a possible treatment for diabetes, but the capacity for new β-cell formation in humans is yet unclear. In young rats, partial pancreatectomy prompts new β-cell formation to restore β-cell mass.