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Autor:
Oliver Korn, Manfred Hallschmid, Kamila Jauch-Chara, Jan Born, Matthias Mölle, Bernd Schultes, Werner Kern, Björn Rasch
Publikováno v:
Diabetes
OBJECTIVE In the treatment of diabetic patients, the long-acting insulin analog insulin detemir is less prone to induce weight gain than other insulin formulations. Assuming that because of its pharmacologic properties, detemir displays stronger cent
Autor:
Leo J. Hofland, Cornelia M. van Duijn, Jacqueline C.M. Witteman, Joseph A M J L Janssen, Michael P. Brugts, Steven W. J. Lamberts
Publikováno v:
Diabetes
OBJECTIVE There is a complex relationship between IGF-I, IGF binding proteins, growth hormone, and insulin. The IGF-I kinase receptor activation assay (KIRA) is a novel method for measuring IGF-I bioactivity in human serum. We speculated that determi
Autor:
Barbara E.K. Klein, Ronald Klein
Publikováno v:
Diabetes
Diabetic retinopathy (DR) was the leading cause of severe visual impairment (VI) in subjects 25–64 years of age in the U.S. 30 to 40 years ago (1,2). At that time, severe VI (best corrected visual acuity of 20/200 or worse in the better eye) was 25
Autor:
Torben Hansen, Lise Højbjerre, Allan Vaag, Mette P. Sonne, Amra Ciric Alibegovic, Oluf Pedersen, Bente Stallknecht, Gerrit van Hall, Flemming Dela, Jens J. Holst
Publikováno v:
Diabetes
Alibegovic, A C, Sonne, M P, Højbjerre, L, Hansen, T, Pedersen, O, van Hall, G, Holst, J J, Stallknecht, B, Dela, F & Vaag, A 2010, ' The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest ', Diabetes, vol. 59, no. 4, pp. 836-43 . https://doi.org/10.2337/db09-0918
Alibegovic, A C, Sonne, M P, Højbjerre, L, Hansen, T, Pedersen, O, van Hall, G, Holst, J J, Stallknecht, B, Dela, F & Vaag, A 2010, ' The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest ', Diabetes, vol. 59, no. 4, pp. 836-43 . https://doi.org/10.2337/db09-0918
OBJECTIVE The aim of this study was to determine whether the type 2 diabetes–associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest
Autor:
David Meyre, Guillaume Paré
Publikováno v:
Diabetes
Cystic fibrosis (CF) is the most common inherited disorder of childhood and is caused by autosomal recessive mutations in the CF transmembrane conductance regulator ( CFTR ) gene (1). CF is most common among Caucasian individuals, with a prevalence o
Publikováno v:
Diabetes
OBJECTIVE Intestinal lipoprotein production has recently been shown to be increased in insulin resistance, but it is not known whether it is regulated by insulin in humans. Here, we investigated the effect of acute hyperinsulinemia on intestinal (and
Autor:
Esa Laurila, Pasi K. Korhonen, Virve M. Lundgren, Leif Groop, Valeriya Lyssenko, Tiinamaija Tuomi, Bo Isomaa
Publikováno v:
Diabetes
OBJECTIVE To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS GADAs were analyzed in 4,976 nondiabetic relatives of type 2
Publikováno v:
Diabetes
OBJECTIVE Reductions in insulin sensitivity in conjunction with muscle mitochondrial dysfunction have been reported to occur in many conditions including aging. The objective was to determine whether insulin resistance and mitochondrial dysfunction a
Autor:
Jean M. Lawrence, Richard M. Watanabe, Lori L. Bonnycastle, Thomas A. Buchanan, Xia Li, Hooman Allayee, Markku Laakso, Heather M. Stringham, Miwa Kawakubo, Yu-Hsiang Shu, Jaana Hartiala, Johanna Kuusisto, Anny H. Xiang, Enrique Trigo, Amy J. Swift
Publikováno v:
Diabetes
OBJECTIVE Glucokinase (GCK) and glucose-6-phosphatase catalytic subunit 2 (G6PC2) regulate the glucose-cycling step in pancreatic β-cells and may regulate insulin secretion. GCK rs1799884 and G6PC2 rs560887 have been independently associated with fa
Autor:
C. Hamish Courtney, Jane McEneny, Michelle Spence, Steven J. Hunter, C. N. Ennis, Ian S. Young, U. Bradley, Patrick M. Bell, Michelle C. McKinley, David R. McCance
Publikováno v:
Diabetes
OBJECTIVE Low-fat hypocaloric diets reduce insulin resistance and prevent type 2 diabetes in those at risk. Low-carbohydrate, high-fat diets are advocated as an alternative, but reciprocal increases in dietary fat may have detrimental effects on insu