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Publikováno v:
Diabetes
Individuals with type 1 diabetes have an impaired glucagon counterregulatory response to hypoglycemia. Sodium—glucose cotransporter (SGLT) inhibitors increase glucagon concentrations. We evaluated whether SGLT inhibition restores the glucagon count
Publikováno v:
Diabetes
Insulin clearance is a highly variable and important factor that affects circulating insulin concentrations. We developed a novel model-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and C-peptide profil
Autor:
Joyce B. J. van Meurs, Eric D. Kolaczyk, Roby Joehanes, Caroline S. Fox, Albert Hofman, Andrew B. Singleton, Jose C. Florez, Andrew D. Johnson, Denis Rybin, Magic Investigators, Jaeyoung Hong, Lorna W. Harries, Lisa Pham, James B. Meigs, André G. Uitterlinden, Daniel Levy, Josée Dupuis, Stefania Bandinelli, Marie-France Hivert, Luigi Ferrucci, Dena G. Hernandez, Luke C. Pilling, Marjolein J. Peters, Brian H. Chen, Peter J. Munson, Abbas Dehghan, John D. Hogan, Saixia Ying, David Melzer
Publikováno v:
Diabetes
Diabetes, 65(12), 3794-3804. American Diabetes Association Inc.
Diabetes, 65(12), 3794-3804. American Diabetes Association Inc.
Genome-wide association studies (GWAS) have successfully identified genetic loci associated with glycemic traits. However, characterizing the functional significance of these loci has proven challenging. We sought to gain insights into the regulation
Autor:
Peter G. Colman, Spiros Fourlanos, Emanuela Martinuzzi, Jeanne Butler, Shane A. Gellert, Leonard C. Harrison, Roberto Mallone, Christine Perry
Publikováno v:
Diabetes
OBJECTIVE Insulin in pancreatic β-cells is a target of autoimmunity in type 1 diabetes. In the NOD mouse model of type 1 diabetes, oral or nasal administration of insulin induces immune tolerance to insulin and protects against autoimmune diabetes.
Autor:
Patrick Schrauwen, Marco Mensink, Denis van Beurden, Esther Moonen-Kornips, Matthijs K. C. Hesselink, Joris Hoeks, Noud A. van Herpen
Publikováno v:
Diabetes, 59(9), 2117-2125
Diabetes
Diabetes 59 (2010) 9
Diabetes, 59(9), 2117-2125. American Diabetes Association
Diabetes
Diabetes 59 (2010) 9
Diabetes, 59(9), 2117-2125. American Diabetes Association
OBJECTIVE Type 2 diabetes and insulin resistance have been associated with mitochondrial dysfunction, but it is debated whether this is a primary factor in the pathogenesis of the disease. To test the concept that mitochondrial dysfunction is seconda
Autor:
Jean M. Lawrence, Richard M. Watanabe, Lori L. Bonnycastle, Thomas A. Buchanan, Xia Li, Hooman Allayee, Markku Laakso, Heather M. Stringham, Miwa Kawakubo, Yu-Hsiang Shu, Jaana Hartiala, Johanna Kuusisto, Anny H. Xiang, Enrique Trigo, Amy J. Swift
Publikováno v:
Diabetes
OBJECTIVE Glucokinase (GCK) and glucose-6-phosphatase catalytic subunit 2 (G6PC2) regulate the glucose-cycling step in pancreatic β-cells and may regulate insulin secretion. GCK rs1799884 and G6PC2 rs560887 have been independently associated with fa
Publikováno v:
Diabetes. 56:2110-2115
Latent autoimmune diabetes in adults or type 1.5 diabetes is considered to be a T-cell–mediated autoimmune disease. However, identification of patients is based commonly on autoantibody (Ab) detection. To determine whether measuring T-cell reactivi
Autor:
Ron G. Rosenfeld, José Manuel Fernández-Real, Abel López-Bermejo, Wifredo Ricart, Maria García-Gil, Javad Khosravi, Roser Casamitjana, Katherine L. Pratt, Vivian Hwa
Publikováno v:
Diabetes. 55:2333-2339
IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) has been shown to bind both IGFs and insulin, albeit with low affinity, and to inhibit insulin signaling. We hypothesized that IGFBP-rP1 is associated with insulin resistance and components of
Autor:
Peter C. Butler, Antoinette Moran, Ryan Galasso, Johannes D. Veldhuis, Juris J. Meier, Bernhard J. Hering, Irene Hong-McAtee
Publikováno v:
Diabetes. 55:2324-2332
Intrahepatic islet transplantation is an experimental therapy for type 1 diabetes. In the present studies, we sought to address the following questions: 1) In humans, do intrahepatic transplanted islets reestablish coordinated puslatile insulin secre
Autor:
Steven S. Rich, Richard N. Bergman, Richard M. Watanabe, Lynne E. Wagenknecht, Steven M. Haffner, James E. Hokanson, Jill M. Norris, Daniel J. Zaccaro, Jerome I. Rotter, Mohammed F. Saad
Publikováno v:
Diabetes. 52:2168-2174
Insulin resistance is an important risk factor for development of type 2 diabetes as well as other chronic conditions, including hypertension, cardiovascular disease, and colon cancer. To find genes for insulin resistance it is necessary to assess in