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Autor:
Kiara C. Eldred, Thomas A. Reh
Publikováno v:
Developmental Biology. 480:114-122
The retina is a complex neuronal structure that converts light energy into visual perception. Many specialized aspects of the primate retina, including a cone rich macula for high acuity vision, ocular size, and cell type diversity are not found in o
Publikováno v:
Dev Biol
Human organoids stand at the forefront of basic and translational research, providing experimentally tractable systems to study human development and disease. These stem cell-derived, in vitro cultures can generate a multitude of tissue and organ typ
Autor:
Jeremy N. Kay, Caitlin E. Paisley
Publikováno v:
Dev Biol
Throughout the central nervous system, astrocytes adopt precisely ordered spatial arrangements of their somata and arbors, which facilitate their many important functions. Astrocyte pattern formation is particularly important in the retina, where ast
Autor:
Masazumi Tada
Publikováno v:
Developmental Biology. 477:1-10
Cell extrusion is a morphogenetic process in which unfit or dying cells are eliminated from the tissue at the interface with healthy neighbours in homeostasis. This process is also highly associated with cell fate specification followed by differenti
Autor:
Sara G. Susco, Jessica Moffitt, Mario A. Arias-Garcia, Zhanyan Fu, Justin Korn, Violeta G. Lopez-Huerta, Amanda Beccard, Lindy E. Barrett, Anne M. Bara
Publikováno v:
Developmental Biology. 468:93-100
Fragile X mental retardation 1 (FMR1) encodes the RNA binding protein FMRP. Loss of FMRP drives Fragile X syndrome (FXS), the leading inherited cause of intellectual disability and a leading monogenic cause of autism. While cortical hyperexcitability
Autor:
Jonathan A. Epstein, Kelvin See, Jun Li, Andrey Poleshko, Anna A. Kiseleva, Cheryl L. Smith, Feiyan Liu
Publikováno v:
Dev Biol
Spatial organization of the genome in the nucleus plays a critical role in development and regulation of transcription. A genomic region that resides at the nuclear periphery is part of the chromatin layer marked with histone H3 lysine 9 dimethyl (H3
Autor:
Fay Cooper, Anestis Tsakiridis
Publikováno v:
Developmental biology. 489
The production of the tissues that make up the mammalian embryonic trunk takes place in a head-tail direction, via the differentiation of posteriorly-located axial progenitor populations. These include bipotent neuromesodermal progenitors (NMPs), whi
Publikováno v:
Developmental Biology. 444:S356-S365
Multipotent neural crest cells can self-renew and give rise to a plethora of neural and non-neural cell types in the vertebrate embryo. Intriguingly, cells reminiscent of such neural crest stem cells (NCSCs) have also been isolated from various postn
Publikováno v:
Developmental Biology. 444:S170-S180
The neural crest is a migratory cell population that contributes to multiple tissues and organs during vertebrate embryonic development. It is remarkable in its ability to differentiate into an array of different cell types, including melanocytes, ca
Publikováno v:
Developmental Biology. 444:S60-S66
The migration and distribution patterns of neural crest (NC) cells reflect the distinct embryonic environments of the head and trunk: cephalic NC cells migrate predominantly along the dorsolateral pathway to populate the craniofacial and pharyngeal r