Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ali H"'
Publikováno v:
Developmental Biology. 408:305-315
Huntington's Disease (HD) is a neurodegenerative disorder that results from the abnormal expansion of poly-glutamine (polyQ) repeats in the Huntingtin (HTT) gene. Although HTT has been linked to a variety of cellular events, it is still not clear wha
Publikováno v:
Developmental Biology. 350(1):13-23
The specification of left–right asymmetry is an evolutionarily conserved developmental process in vertebrates. The interplay between two TGFβ ligands, Derrière/GDF1 and Xnr1/Nodal, together with inhibitors such as Lefty and Coco/Cerl2, have been
Autor:
Felix Naef, Makiko Uchida, Ignacio Munoz Sanjuan, Noboru Sato, Ali H. Brivanlou, Michael Heke
Publikováno v:
Developmental Biology. 260(2):404-413
The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first global transcriptional profile of the state of “stemness” in human embryonic stem cells (HESCs). We have identified a set of 918 genes enriched in undi
Autor:
Chang, CB, Eggen, BJL, Weinstein, DC, Brivanlou, AH, Chang, Chenbei, Weinstein, Daniel C., Brivanlou, Ali H.
Publikováno v:
Developmental Biology, 255(1), 1-11. ACADEMIC PRESS INC ELSEVIER SCIENCE
During early vertebrate development, members of the transforming growth factor beta (TGFbeta) family play important roles in a variety of processes, including germ layer specification, patterning, cell differentiation, migration, and organogenesis. T
Publikováno v:
Developmental Biology. 254(1):50-67
Appropriate blood supply and vascular development are necessary in development and in cancer, heart disease, and diabetes. Here, we report the use of DiI-labeled acetylated low-density lipoprotein (DiI-Ac-LDL) to label endothelial cells and character
Publikováno v:
Developmental Biology. 237(1):1-17
One of the central questions in developmental biology is that of how one cell can give rise to all specialized cell types and organs in the organism. Within the embryo, all tissues are composed of cells derived from one or more of the three germ laye
Autor:
Alexander Sczyrba, Stefan Bekiranov, Terry Gaasterland, Ali H. Brivanlou, Esther Bell, Curtis R. Altmann, Jason Pun
Publikováno v:
Developmental Biology. 236(1):64-75
In order to examine transcriptional regulation globally, during early vertebrate embryonic development, we have prepared Xenopus laevis cDNA microarrays. These prototype embryonic arrays contain 864 sequenced gastrula cDNA. In order to analyze and st
Autor:
Ariel J. Levine, Ali H. Brivanlou
Publikováno v:
Developmental biology. 308(2)
How does the vertebrate embryo make a nervous system? This complex question has been at the center of developmental biology for many years. The earliest step in this process – the induction of neural tissue – is intimately linked to patterning of
Autor:
Alin Vonica, Ali H. Brivanlou
Publikováno v:
Developmental biology. 303(1)
Formation of the left-right axis involves a symmetry-breaking signal originating in the node or its equivalents, which increases TGF-beta signaling on the left side of the embryo and ultimately leads to asymmetric patterning of the viscera. DAN domai
Publikováno v:
Developmental biology. 292(2)
Signaling mechanisms underlying the induction of the pre-pancreatic tissue within the endoderm remain poorly understood. Through an expression cloning strategy, we have identified a previously uncharacterized pancreatic factor that we named Shirin. I